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Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa

We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalan...

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Autores principales: Ramlagan, Shandir, Rodriguez, Violeta J., Peltzer, Karl, Ruiter, Robert A. C., Jones, Deborah L., Sifunda, Sibusiso
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766468/
https://www.ncbi.nlm.nih.gov/pubmed/31228026
http://dx.doi.org/10.1007/s10461-019-02563-z
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author Ramlagan, Shandir
Rodriguez, Violeta J.
Peltzer, Karl
Ruiter, Robert A. C.
Jones, Deborah L.
Sifunda, Sibusiso
author_facet Ramlagan, Shandir
Rodriguez, Violeta J.
Peltzer, Karl
Ruiter, Robert A. C.
Jones, Deborah L.
Sifunda, Sibusiso
author_sort Ramlagan, Shandir
collection PubMed
description We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care. Trial registration Clinicaltrials.gov: number NCT02085356.
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spelling pubmed-67664682019-10-09 Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa Ramlagan, Shandir Rodriguez, Violeta J. Peltzer, Karl Ruiter, Robert A. C. Jones, Deborah L. Sifunda, Sibusiso AIDS Behav Original Paper We evaluate the impact of a multi-session cognitive behavioral prevention of mother to child transmission (PMTCT) intervention on antiretroviral therapy (ART) adherence. A total of 683 women were enrolled into a randomized control trial conducted at twelve community health centres (CHCs) in Mpumalanga Province. Participants were randomized to Standard Care or Enhanced PMTCT Intervention (EI). EI received three group and three individual intervention sessions. EI impact was ascertained on ART adherence (baseline vs 12 months post-partum). Women in the intervention groups were less likely to remain stable with regards to ART adherence over time compared to the control groups. In predicting if women become adherent over time, the intervention condition had no impact. However, the intervention condition was significantly positively associated with change to non-adherence. The enhanced cognitive-behavioral PMTCT intervention did not show any improvement in relation to maternal ART adherence relative to standard PMTCT care. Trial registration Clinicaltrials.gov: number NCT02085356. Springer US 2019-06-21 2019 /pmc/articles/PMC6766468/ /pubmed/31228026 http://dx.doi.org/10.1007/s10461-019-02563-z Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Paper
Ramlagan, Shandir
Rodriguez, Violeta J.
Peltzer, Karl
Ruiter, Robert A. C.
Jones, Deborah L.
Sifunda, Sibusiso
Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title_full Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title_fullStr Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title_full_unstemmed Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title_short Self-Reported Long-Term Antiretroviral Adherence: A Longitudinal Study Among HIV Infected Pregnant Women in Mpumalanga, South Africa
title_sort self-reported long-term antiretroviral adherence: a longitudinal study among hiv infected pregnant women in mpumalanga, south africa
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766468/
https://www.ncbi.nlm.nih.gov/pubmed/31228026
http://dx.doi.org/10.1007/s10461-019-02563-z
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