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Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review
BACKGROUND: Gastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments. OBJECTIVE: To evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766488/ https://www.ncbi.nlm.nih.gov/pubmed/31313372 http://dx.doi.org/10.1111/jvim.15554 |
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author | Jensen, Anders P. Bjørnvad, Charlotte R. |
author_facet | Jensen, Anders P. Bjørnvad, Charlotte R. |
author_sort | Jensen, Anders P. |
collection | PubMed |
description | BACKGROUND: Gastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments. OBJECTIVE: To evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment. METHODS: A systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size. RESULTS: One hundred sixty‐five studies were identified, of which 17 met the inclusion criteria—12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable. CONCLUSIONS AND CLINICAL IMPORTANCE: The current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies. |
format | Online Article Text |
id | pubmed-6766488 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67664882019-09-30 Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review Jensen, Anders P. Bjørnvad, Charlotte R. J Vet Intern Med SMALL ANIMAL BACKGROUND: Gastrointestinal diseases are prevalent in dogs, and probiotics could provide safe alternatives to conventional treatments. OBJECTIVE: To evaluate the clinical effects of probiotics when used in the prevention or treatment of gastrointestinal disease in dogs compared with no treatment, only symptomatic treatment, or conventional treatment. METHODS: A systematic review was preformed searching AGRICOLA, AGRIS, CAB Abstracts, Embase, Ovid MEDLINE, and Web of Science to identify articles published before April 1, 2017. Selection criteria were original research report, those published in peer reviewed journal, and study investigating in vivo use of probiotic for prevention or treatment of gastrointestinal disease in dogs. Studies were rated based on the level of evidence, and methodological quality was evaluated by the following variables: similarities between groups at baseline, risk of bias, and study group size. RESULTS: One hundred sixty‐five studies were identified, of which 17 met the inclusion criteria—12 concerned acute gastrointestinal disease and 5 concerned chronic gastrointestinal disease. The level of evidence ranged between randomized controlled studies and crossover uncontrolled trials; estimated risk of bias was generally moderate to high; and sample sizes were small. Feces consistency was the most frequently evaluated clinical variable. CONCLUSIONS AND CLINICAL IMPORTANCE: The current data point toward a very limited and possibly clinically unimportant effect for prevention or treatment of acute gastrointestinal disease. For chronic gastrointestinal disease, dietary intervention remains the major key in treatment, whereas probiotic supplement seems not to add significant improvement. However, studies were often underpowered, underscoring the need for future larger, preferably multicenter studies. John Wiley & Sons, Inc. 2019-07-16 2019 /pmc/articles/PMC6766488/ /pubmed/31313372 http://dx.doi.org/10.1111/jvim.15554 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Jensen, Anders P. Bjørnvad, Charlotte R. Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title | Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title_full | Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title_fullStr | Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title_full_unstemmed | Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title_short | Clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: A systematic review |
title_sort | clinical effect of probiotics in prevention or treatment of gastrointestinal disease in dogs: a systematic review |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766488/ https://www.ncbi.nlm.nih.gov/pubmed/31313372 http://dx.doi.org/10.1111/jvim.15554 |
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