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Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure
BACKGROUND: Cardiac cachexia, loss of muscle mass associated with congestive heart failure (CHF), is associated with increased morbidity and shorter survival times in people, but an association between cardiac cachexia and survival has not been reported in dogs. OBJECTIVES: To determine the prevalen...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766489/ https://www.ncbi.nlm.nih.gov/pubmed/31317600 http://dx.doi.org/10.1111/jvim.15566 |
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author | Ineson, Deanna L. Freeman, Lisa M. Rush, John E. |
author_facet | Ineson, Deanna L. Freeman, Lisa M. Rush, John E. |
author_sort | Ineson, Deanna L. |
collection | PubMed |
description | BACKGROUND: Cardiac cachexia, loss of muscle mass associated with congestive heart failure (CHF), is associated with increased morbidity and shorter survival times in people, but an association between cardiac cachexia and survival has not been reported in dogs. OBJECTIVES: To determine the prevalence of cachexia and its associations with clinical, laboratory, and survival data in dogs with CHF. ANIMALS: Two hundred sixty‐nine dogs with CHF. METHODS: Retrospective cohort study. Cachexia was defined by 1 of 2 definitions: (1) mild, moderate, or severe muscle loss or (2) weight loss of ≥5% in 12 months or less. Variables were compared between dogs with and without cachexia. RESULTS: One hundred thirty of 269 dogs (48.3%) had cardiac cachexia based on muscle loss, whereas 67 of 159 dogs (42.1%) with pre‐evaluation body weights had cachexia based on weight loss. Dogs with cachexia (based on muscle loss) were significantly older (P = .05), more likely to have a cardiac arrhythmia (P = .02), had higher chloride concentrations (P = .04), and had a lower body condition score (P < .001), hematocrit (P = .006), hemoglobin (P = .006), and albumin (P = .004) concentrations. On multivariable analysis, cachexia (P = .05), clinically important tachyarrhythmias (P < .001), azotemia (P < .001), and being under‐ or overweight (both P = .003) were associated with shorter survival times. CONCLUSIONS AND CLINICAL IMPORTANCE: Cardiac cachexia in common in dogs with CHF and is associated with significantly shorter survival. This emphasizes the importance of preventing, diagnosing, and treating muscle loss in dogs with CHF. |
format | Online Article Text |
id | pubmed-6766489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67664892019-09-30 Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure Ineson, Deanna L. Freeman, Lisa M. Rush, John E. J Vet Intern Med SMALL ANIMAL BACKGROUND: Cardiac cachexia, loss of muscle mass associated with congestive heart failure (CHF), is associated with increased morbidity and shorter survival times in people, but an association between cardiac cachexia and survival has not been reported in dogs. OBJECTIVES: To determine the prevalence of cachexia and its associations with clinical, laboratory, and survival data in dogs with CHF. ANIMALS: Two hundred sixty‐nine dogs with CHF. METHODS: Retrospective cohort study. Cachexia was defined by 1 of 2 definitions: (1) mild, moderate, or severe muscle loss or (2) weight loss of ≥5% in 12 months or less. Variables were compared between dogs with and without cachexia. RESULTS: One hundred thirty of 269 dogs (48.3%) had cardiac cachexia based on muscle loss, whereas 67 of 159 dogs (42.1%) with pre‐evaluation body weights had cachexia based on weight loss. Dogs with cachexia (based on muscle loss) were significantly older (P = .05), more likely to have a cardiac arrhythmia (P = .02), had higher chloride concentrations (P = .04), and had a lower body condition score (P < .001), hematocrit (P = .006), hemoglobin (P = .006), and albumin (P = .004) concentrations. On multivariable analysis, cachexia (P = .05), clinically important tachyarrhythmias (P < .001), azotemia (P < .001), and being under‐ or overweight (both P = .003) were associated with shorter survival times. CONCLUSIONS AND CLINICAL IMPORTANCE: Cardiac cachexia in common in dogs with CHF and is associated with significantly shorter survival. This emphasizes the importance of preventing, diagnosing, and treating muscle loss in dogs with CHF. John Wiley & Sons, Inc. 2019-07-17 2019 /pmc/articles/PMC6766489/ /pubmed/31317600 http://dx.doi.org/10.1111/jvim.15566 Text en © 2019 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | SMALL ANIMAL Ineson, Deanna L. Freeman, Lisa M. Rush, John E. Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title | Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title_full | Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title_fullStr | Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title_full_unstemmed | Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title_short | Clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
title_sort | clinical and laboratory findings and survival time associated with cardiac cachexia in dogs with congestive heart failure |
topic | SMALL ANIMAL |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766489/ https://www.ncbi.nlm.nih.gov/pubmed/31317600 http://dx.doi.org/10.1111/jvim.15566 |
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