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Porcine placental extract facilitates memory and learning in aged mice

Aging induces a decline in both memory and learning ability without predisposing an individual to diseases of the central nervous system, such as dementia. This decline can have a variety of adverse effects on daily life, and it can also gradually affect the individual and the people they are surrou...

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Autores principales: Yamauchi, Akihiro, Tone, Takahiro, Sugimoto, Koji, Seok Lim, Hong, Kaku, Taiichi, Tohda, Chihiro, Shindo, Takayuki, Tamada, Koji, Mizukami, Yoichi, Hirano, Eiichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766592/
https://www.ncbi.nlm.nih.gov/pubmed/31572593
http://dx.doi.org/10.1002/fsn3.1156
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author Yamauchi, Akihiro
Tone, Takahiro
Sugimoto, Koji
Seok Lim, Hong
Kaku, Taiichi
Tohda, Chihiro
Shindo, Takayuki
Tamada, Koji
Mizukami, Yoichi
Hirano, Eiichi
author_facet Yamauchi, Akihiro
Tone, Takahiro
Sugimoto, Koji
Seok Lim, Hong
Kaku, Taiichi
Tohda, Chihiro
Shindo, Takayuki
Tamada, Koji
Mizukami, Yoichi
Hirano, Eiichi
author_sort Yamauchi, Akihiro
collection PubMed
description Aging induces a decline in both memory and learning ability without predisposing an individual to diseases of the central nervous system, such as dementia. This decline can have a variety of adverse effects on daily life, and it can also gradually affect the individual and the people they are surrounded by. Since recent evidence indicated that placental extract has effects on brain function such as memory, we hypothesized that placental extract could ameliorate the age‐associated reduction in cognitive function in aging. Here, we investigated the effect of new modified porcine placental extract (SD‐F) on memory ability in aged mice at both the behavioral and molecular levels. Our results revealed that SD‐F significantly enhanced memory ability in the object recognition and object location tasks in a dose‐dependent manner in aged mice relative to controls. The numbers of Nissl‐positive cells in the hippocampal cornu ammonis 3 (CA3) and dentate gyrus (DG) regions were increased in SD‐F‐treated aged mice relative to controls. RNA‐seq analysis of the hippocampus of aged mice identified 542 differentially expressed genes, of which 216 were up‐regulated and 326 were down‐regulated in SD‐F‐treated mice relative to controls. Of the 216 up‐regulated genes, we identified four characteristic genes directly related to memory, including early growth response protein 1 (Egr1), growth arrest and DNA‐damage‐inducible, beta (Gadd45b), NGFI‐A binding protein 2 (Nab2), and vascular endothelial growth factor a (Vegfa). These results suggest that the efficacy of SD‐F involves upregulation of these genes.
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spelling pubmed-67665922019-09-30 Porcine placental extract facilitates memory and learning in aged mice Yamauchi, Akihiro Tone, Takahiro Sugimoto, Koji Seok Lim, Hong Kaku, Taiichi Tohda, Chihiro Shindo, Takayuki Tamada, Koji Mizukami, Yoichi Hirano, Eiichi Food Sci Nutr Original Research Aging induces a decline in both memory and learning ability without predisposing an individual to diseases of the central nervous system, such as dementia. This decline can have a variety of adverse effects on daily life, and it can also gradually affect the individual and the people they are surrounded by. Since recent evidence indicated that placental extract has effects on brain function such as memory, we hypothesized that placental extract could ameliorate the age‐associated reduction in cognitive function in aging. Here, we investigated the effect of new modified porcine placental extract (SD‐F) on memory ability in aged mice at both the behavioral and molecular levels. Our results revealed that SD‐F significantly enhanced memory ability in the object recognition and object location tasks in a dose‐dependent manner in aged mice relative to controls. The numbers of Nissl‐positive cells in the hippocampal cornu ammonis 3 (CA3) and dentate gyrus (DG) regions were increased in SD‐F‐treated aged mice relative to controls. RNA‐seq analysis of the hippocampus of aged mice identified 542 differentially expressed genes, of which 216 were up‐regulated and 326 were down‐regulated in SD‐F‐treated mice relative to controls. Of the 216 up‐regulated genes, we identified four characteristic genes directly related to memory, including early growth response protein 1 (Egr1), growth arrest and DNA‐damage‐inducible, beta (Gadd45b), NGFI‐A binding protein 2 (Nab2), and vascular endothelial growth factor a (Vegfa). These results suggest that the efficacy of SD‐F involves upregulation of these genes. John Wiley and Sons Inc. 2019-08-15 /pmc/articles/PMC6766592/ /pubmed/31572593 http://dx.doi.org/10.1002/fsn3.1156 Text en © 2019 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Yamauchi, Akihiro
Tone, Takahiro
Sugimoto, Koji
Seok Lim, Hong
Kaku, Taiichi
Tohda, Chihiro
Shindo, Takayuki
Tamada, Koji
Mizukami, Yoichi
Hirano, Eiichi
Porcine placental extract facilitates memory and learning in aged mice
title Porcine placental extract facilitates memory and learning in aged mice
title_full Porcine placental extract facilitates memory and learning in aged mice
title_fullStr Porcine placental extract facilitates memory and learning in aged mice
title_full_unstemmed Porcine placental extract facilitates memory and learning in aged mice
title_short Porcine placental extract facilitates memory and learning in aged mice
title_sort porcine placental extract facilitates memory and learning in aged mice
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766592/
https://www.ncbi.nlm.nih.gov/pubmed/31572593
http://dx.doi.org/10.1002/fsn3.1156
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