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Misfolded proinsulin impairs processing of precursor of insulin receptor and insulin signaling in β cells

Insulin resistance in classic insulin-responsive tissues is a hallmark of type 2 diabetes (T2D). However, the pathologic significance of β-cell insulin resistance and the underlying mechanisms contributing to defective insulin signaling in β cells remain largely unknown. Emerging evidence indicates...

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Detalles Bibliográficos
Autores principales:	Liu, Shiqun, Li, Xin, Yang, Jing, Zhu, Ruimin, Fan, Zhenqian, Xu, Xiaoxi, Feng, Wenli, Cui, Jingqiu, Sun, Jinhong, Liu, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Federation of American Societies for Experimental Biology 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766638/ https://www.ncbi.nlm.nih.gov/pubmed/31311313 http://dx.doi.org/10.1096/fj.201900442R

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