Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma

BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC‐Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC). METHODS: In 149 FN...

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Autores principales: van Schaik, Jeroen E., Muller Kobold, Anna C., van der Laan, Bernard F. A. M., van der Vegt, Bert, van Hemel, Bettien M., Plaat, Boudewijn E. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766850/
https://www.ncbi.nlm.nih.gov/pubmed/30828886
http://dx.doi.org/10.1002/hed.25733
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author van Schaik, Jeroen E.
Muller Kobold, Anna C.
van der Laan, Bernard F. A. M.
van der Vegt, Bert
van Hemel, Bettien M.
Plaat, Boudewijn E. C.
author_facet van Schaik, Jeroen E.
Muller Kobold, Anna C.
van der Laan, Bernard F. A. M.
van der Vegt, Bert
van Hemel, Bettien M.
Plaat, Boudewijn E. C.
author_sort van Schaik, Jeroen E.
collection PubMed
description BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC‐Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC). METHODS: In 149 FNA samples of 114 patients, SCC‐Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection. RESULTS: SCC‐Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC‐Ag has 96% sensitivity for detecting HNSCC. CONCLUSIONS: SCC‐Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes.
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spelling pubmed-67668502019-10-01 Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma van Schaik, Jeroen E. Muller Kobold, Anna C. van der Laan, Bernard F. A. M. van der Vegt, Bert van Hemel, Bettien M. Plaat, Boudewijn E. C. Head Neck Original Articles BACKGROUND: The purpose of this study was to determine the additional diagnostic value of squamous cell carcinoma antigen (SCC‐Ag) in cervical lymph node fine needle aspiration (FNA) samples for the detection of regional metastases of head and neck squamous cell carcinoma (HNSCC). METHODS: In 149 FNA samples of 114 patients, SCC‐Ag concentration was retrospectively analyzed and associated with diagnosis to establish a cutoff concentration in relation to sensitivity and specificity of HNSCC detection. RESULTS: SCC‐Ag was elevated in lymph nodes from patients with HNSCC compared to lymph nodes from other patients (P < 0.01). With 0.3 μg/L as the cutoff concentration, SCC‐Ag has 96% sensitivity for detecting HNSCC. CONCLUSIONS: SCC‐Ag in FNA is a reliable test for detecting HNSCC in cervical lymph nodes. John Wiley & Sons, Inc. 2019-03-04 2019-08 /pmc/articles/PMC6766850/ /pubmed/30828886 http://dx.doi.org/10.1002/hed.25733 Text en © 2019 The Authors. Head & Neck published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
van Schaik, Jeroen E.
Muller Kobold, Anna C.
van der Laan, Bernard F. A. M.
van der Vegt, Bert
van Hemel, Bettien M.
Plaat, Boudewijn E. C.
Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title_full Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title_fullStr Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title_full_unstemmed Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title_short Squamous cell carcinoma antigen concentration in fine needle aspiration samples: A new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
title_sort squamous cell carcinoma antigen concentration in fine needle aspiration samples: a new method to detect cervical lymph node metastases of head and neck squamous cell carcinoma
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766850/
https://www.ncbi.nlm.nih.gov/pubmed/30828886
http://dx.doi.org/10.1002/hed.25733
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