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Inducing the Degradation of Disease-Related Proteins Using Heterobifunctional Molecules
Current drug development strategies that target either enzymatic or receptor proteins for which specific small molecule ligands can be designed for modulation, result in a large portion of the proteome being overlooked as undruggable. The recruitment of natural degradation cascades for targeted prot...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766870/ https://www.ncbi.nlm.nih.gov/pubmed/31500395 http://dx.doi.org/10.3390/molecules24183272 |