NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas

Extraskeletal myxoid chondrosarcoma (EMC) is a rare sarcoma histotype with uncertain differentiation. EMC is hallmarked by the rearrangement of the NR4A3 gene, which in most cases fuses with EWSR1 or TAF15. TAF15‐translocated EMC seem to feature a more aggressive course compared to EWSR1‐positive EM...

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Detalles Bibliográficos
Autores principales: Brenca, Monica, Stacchiotti, Silvia, Fassetta, Kelly, Sbaraglia, Marta, Janjusevic, Milijana, Racanelli, Dominga, Polano, Maurizio, Rossi, Sabrina, Brich, Silvia, Dagrada, Gian P, Collini, Paola, Colombo, Chiara, Gronchi, Alessandro, Astolfi, Annalisa, Indio, Valentina, Pantaleo, Maria A, Picci, Piero, Casali, Paolo G, Dei Tos, Angelo P, Pilotti, Silvana, Maestro, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd. 2019
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6766969/
https://www.ncbi.nlm.nih.gov/pubmed/31020999
http://dx.doi.org/10.1002/path.5284

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