CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease

BACKGROUND: Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. RESULTS: The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. CONCLUSION: In this review, we focus on the role of CXCR4/C...

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Detalles Bibliográficos
Autores principales: De Filippo, Katia, Rankin, Sara M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Neutrophils. Guest Editor: Dirk Roos
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767022/
https://www.ncbi.nlm.nih.gov/pubmed/29734477
http://dx.doi.org/10.1111/eci.12949
Descripción
Sumario:BACKGROUND: Chemokines play a critical role in orchestrating the distribution and trafficking of neutrophils in homeostasis and disease. RESULTS: The CXCR4/CXCL12 chemokine axis has been identified as a central regulator of these processes. CONCLUSION: In this review, we focus on the role of CXCR4/CXCL12 chemokine axis in regulating neutrophil release from the bone marrow and the trafficking of senescent neutrophils back to the bone marrow for clearance under homeostasis and disease. We also discuss the role of CXCR4 in fine‐tuning neutrophil responses in the context of inflammation.

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