A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol

Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and...

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Autores principales: Kalampaliki, Amalia D., Giannouli, Vassiliki, Skaltsounis, Alexios-Leandros, Kostakis, Ioannis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767028/
https://www.ncbi.nlm.nih.gov/pubmed/31492013
http://dx.doi.org/10.3390/molecules24183239
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author Kalampaliki, Amalia D.
Giannouli, Vassiliki
Skaltsounis, Alexios-Leandros
Kostakis, Ioannis K.
author_facet Kalampaliki, Amalia D.
Giannouli, Vassiliki
Skaltsounis, Alexios-Leandros
Kostakis, Ioannis K.
author_sort Kalampaliki, Amalia D.
collection PubMed
description Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation.
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spelling pubmed-67670282019-10-02 A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol Kalampaliki, Amalia D. Giannouli, Vassiliki Skaltsounis, Alexios-Leandros Kostakis, Ioannis K. Molecules Article Hydroxytyrosol and two other polyphenols of olive tree, hydroxytyrosol acetate and 3,4-dihydroxyphenylglycol, are known for a wide range of beneficial activities in human health and prevention from diseases. The inability to isolate high, pure amounts of these natural compounds and the difficult and laborious procedures for the synthesis of them led us to describe herein an efficient, easy, cheap, and scaling up synthetic procedure, from catechol, via microwave irradiation. MDPI 2019-09-05 /pmc/articles/PMC6767028/ /pubmed/31492013 http://dx.doi.org/10.3390/molecules24183239 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalampaliki, Amalia D.
Giannouli, Vassiliki
Skaltsounis, Alexios-Leandros
Kostakis, Ioannis K.
A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title_full A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title_fullStr A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title_full_unstemmed A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title_short A Three-Step, Gram-Scale Synthesis of Hydroxytyrosol, Hydroxytyrosol Acetate, and 3,4-Dihydroxyphenylglycol
title_sort three-step, gram-scale synthesis of hydroxytyrosol, hydroxytyrosol acetate, and 3,4-dihydroxyphenylglycol
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767028/
https://www.ncbi.nlm.nih.gov/pubmed/31492013
http://dx.doi.org/10.3390/molecules24183239
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