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Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?

Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturati...

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Detalles Bibliográficos
Autores principales: Boudreault, Simon, Roy, Patricia, Lemay, Guy, Bisaillon, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767064/
https://www.ncbi.nlm.nih.gov/pubmed/31034770
http://dx.doi.org/10.1002/wrna.1543
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author Boudreault, Simon
Roy, Patricia
Lemay, Guy
Bisaillon, Martin
author_facet Boudreault, Simon
Roy, Patricia
Lemay, Guy
Bisaillon, Martin
author_sort Boudreault, Simon
collection PubMed
description Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturation step that allows exons, or parts of exons, and introns to be retained in mature transcripts, thereby expanding proteome diversity and function. AS is widespread in higher eukaryotes, as it is estimated that nearly all genes in humans are alternatively spliced. Recent evidence has shown that upon infection by numerous viruses, the AS landscape of host‐cells is affected. In this review, we summarize recent advances in our understanding of how virus infection impacts the AS of cellular transcripts. We also present various molecular mechanisms allowing viruses to modulate cellular AS. Finally, the functional consequences of these changes in the RNA splicing signatures during virus–host interactions are discussed. This article is categorized under: RNA in Disease and Development > RNA in Disease. RNA Processing > Splicing Regulation/Alternative Splicing.
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spelling pubmed-67670642019-10-01 Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? Boudreault, Simon Roy, Patricia Lemay, Guy Bisaillon, Martin Wiley Interdiscip Rev RNA Advanced Reviews Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturation step that allows exons, or parts of exons, and introns to be retained in mature transcripts, thereby expanding proteome diversity and function. AS is widespread in higher eukaryotes, as it is estimated that nearly all genes in humans are alternatively spliced. Recent evidence has shown that upon infection by numerous viruses, the AS landscape of host‐cells is affected. In this review, we summarize recent advances in our understanding of how virus infection impacts the AS of cellular transcripts. We also present various molecular mechanisms allowing viruses to modulate cellular AS. Finally, the functional consequences of these changes in the RNA splicing signatures during virus–host interactions are discussed. This article is categorized under: RNA in Disease and Development > RNA in Disease. RNA Processing > Splicing Regulation/Alternative Splicing. John Wiley & Sons, Inc. 2019-04-29 2019 /pmc/articles/PMC6767064/ /pubmed/31034770 http://dx.doi.org/10.1002/wrna.1543 Text en © 2019 The Authors. WIREs RNA published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Advanced Reviews
Boudreault, Simon
Roy, Patricia
Lemay, Guy
Bisaillon, Martin
Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title_full Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title_fullStr Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title_full_unstemmed Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title_short Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
title_sort viral modulation of cellular rna alternative splicing: a new key player in virus–host interactions?
topic Advanced Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767064/
https://www.ncbi.nlm.nih.gov/pubmed/31034770
http://dx.doi.org/10.1002/wrna.1543
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