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Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions?
Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturati...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767064/ https://www.ncbi.nlm.nih.gov/pubmed/31034770 http://dx.doi.org/10.1002/wrna.1543 |
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author | Boudreault, Simon Roy, Patricia Lemay, Guy Bisaillon, Martin |
author_facet | Boudreault, Simon Roy, Patricia Lemay, Guy Bisaillon, Martin |
author_sort | Boudreault, Simon |
collection | PubMed |
description | Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturation step that allows exons, or parts of exons, and introns to be retained in mature transcripts, thereby expanding proteome diversity and function. AS is widespread in higher eukaryotes, as it is estimated that nearly all genes in humans are alternatively spliced. Recent evidence has shown that upon infection by numerous viruses, the AS landscape of host‐cells is affected. In this review, we summarize recent advances in our understanding of how virus infection impacts the AS of cellular transcripts. We also present various molecular mechanisms allowing viruses to modulate cellular AS. Finally, the functional consequences of these changes in the RNA splicing signatures during virus–host interactions are discussed. This article is categorized under: RNA in Disease and Development > RNA in Disease. RNA Processing > Splicing Regulation/Alternative Splicing. |
format | Online Article Text |
id | pubmed-6767064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67670642019-10-01 Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? Boudreault, Simon Roy, Patricia Lemay, Guy Bisaillon, Martin Wiley Interdiscip Rev RNA Advanced Reviews Upon viral infection, a tug of war is triggered between host cells and viruses to maintain/gain control of vital cellular functions, the result of which will ultimately dictate the fate of the host cell. Among these essential cellular functions, alternative splicing (AS) is an important RNA maturation step that allows exons, or parts of exons, and introns to be retained in mature transcripts, thereby expanding proteome diversity and function. AS is widespread in higher eukaryotes, as it is estimated that nearly all genes in humans are alternatively spliced. Recent evidence has shown that upon infection by numerous viruses, the AS landscape of host‐cells is affected. In this review, we summarize recent advances in our understanding of how virus infection impacts the AS of cellular transcripts. We also present various molecular mechanisms allowing viruses to modulate cellular AS. Finally, the functional consequences of these changes in the RNA splicing signatures during virus–host interactions are discussed. This article is categorized under: RNA in Disease and Development > RNA in Disease. RNA Processing > Splicing Regulation/Alternative Splicing. John Wiley & Sons, Inc. 2019-04-29 2019 /pmc/articles/PMC6767064/ /pubmed/31034770 http://dx.doi.org/10.1002/wrna.1543 Text en © 2019 The Authors. WIREs RNA published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Advanced Reviews Boudreault, Simon Roy, Patricia Lemay, Guy Bisaillon, Martin Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title | Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title_full | Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title_fullStr | Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title_full_unstemmed | Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title_short | Viral modulation of cellular RNA alternative splicing: A new key player in virus–host interactions? |
title_sort | viral modulation of cellular rna alternative splicing: a new key player in virus–host interactions? |
topic | Advanced Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767064/ https://www.ncbi.nlm.nih.gov/pubmed/31034770 http://dx.doi.org/10.1002/wrna.1543 |
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