Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase

Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tr...

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Detalles Bibliográficos
Autores principales: Huggins, Ian J., Medina, Carlos A., Springer, Aaron D., van den Berg, Arjen, Jadhav, Satish, Cui, Xianshu, Dowdy, Steven F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767100/
https://www.ncbi.nlm.nih.gov/pubmed/31509944
http://dx.doi.org/10.3390/molecules24183287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767100/
https://www.ncbi.nlm.nih.gov/pubmed/31509944
http://dx.doi.org/10.3390/molecules24183287

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