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Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture)
Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I‐specific inhibitory killer immunoglobulin‐like receptors (KIR) and of the main activating receptors...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767140/ https://www.ncbi.nlm.nih.gov/pubmed/30828978 http://dx.doi.org/10.1111/tan.13509 |
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author | Falco, Michela Pende, Daniela Munari, Enrico Vacca, Paola Mingari, Maria C. Moretta, Lorenzo |
author_facet | Falco, Michela Pende, Daniela Munari, Enrico Vacca, Paola Mingari, Maria C. Moretta, Lorenzo |
author_sort | Falco, Michela |
collection | PubMed |
description | Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I‐specific inhibitory killer immunoglobulin‐like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK‐mediated anti‐leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high‐risk leukemia. |
format | Online Article Text |
id | pubmed-6767140 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Blackwell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-67671402019-10-03 Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) Falco, Michela Pende, Daniela Munari, Enrico Vacca, Paola Mingari, Maria C. Moretta, Lorenzo HLA Review Article Natural killer (NK) cells are innate immune effector cells involved in the first line of defense against viral infections and malignancies. In the last three decades, the identification of HLA class I‐specific inhibitory killer immunoglobulin‐like receptors (KIR) and of the main activating receptors has strongly improved our understanding of the mechanisms regulating NK cell functions. The increased knowledge on how NK cells discriminate healthy cells from damaged cells has made it possible to transfer basic research notions to clinical applications. Of particular relevance is the strong NK‐mediated anti‐leukemia effect in haploidentical hematopoietic stem cell transplantation to cure high‐risk leukemia. Blackwell Publishing Ltd 2019-03-25 2019-04 /pmc/articles/PMC6767140/ /pubmed/30828978 http://dx.doi.org/10.1111/tan.13509 Text en © 2019 The Authors HLA: Immune Response Genetics Published by John Wiley & Sons Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Falco, Michela Pende, Daniela Munari, Enrico Vacca, Paola Mingari, Maria C. Moretta, Lorenzo Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title | Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title_full | Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title_fullStr | Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title_full_unstemmed | Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title_short | Natural killer cells: From surface receptors to the cure of high‐risk leukemia (Ceppellini Lecture) |
title_sort | natural killer cells: from surface receptors to the cure of high‐risk leukemia (ceppellini lecture) |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767140/ https://www.ncbi.nlm.nih.gov/pubmed/30828978 http://dx.doi.org/10.1111/tan.13509 |
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