Synthesis of Cyclobutane Analogue 4: Preparation of Purine and Pyrimidine Carbocyclic Nucleoside Derivatives

The coupling of 2-bromo-3-benzoyloxycyclobutanone with purine under basic conditions produces two regioisomers consisting of the N-7 and N-9 alkylated products in equal amounts in their racemic forms. The distribution of the isomers is consistent with the charge delocalization between the N-7 and N-...

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Detalles Bibliográficos
Autores principales: Hasaneen, Noha, Ebead, Abdelaziz, Hassan, Muhammad Murtaza, Afifi, Hanan, Hunter, Howard, Lee-Ruff, Edward, El-Gohary, Nadia S., Maarouf, Azza R., El-Emam, Ali A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767184/
https://www.ncbi.nlm.nih.gov/pubmed/31491981
http://dx.doi.org/10.3390/molecules24183235

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