Cargando…
Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivat...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767220/ https://www.ncbi.nlm.nih.gov/pubmed/31505754 http://dx.doi.org/10.3390/molecules24183277 |
_version_ | 1783454866695258112 |
---|---|
author | Theodosis-Nobelos, Panagiotis Papagiouvannis, Georgios Kourounakis, Panos N. Rekka, Eleni A. |
author_facet | Theodosis-Nobelos, Panagiotis Papagiouvannis, Georgios Kourounakis, Panos N. Rekka, Eleni A. |
author_sort | Theodosis-Nobelos, Panagiotis |
collection | PubMed |
description | Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress. |
format | Online Article Text |
id | pubmed-6767220 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67672202019-10-02 Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam Theodosis-Nobelos, Panagiotis Papagiouvannis, Georgios Kourounakis, Panos N. Rekka, Eleni A. Molecules Article Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress. MDPI 2019-09-09 /pmc/articles/PMC6767220/ /pubmed/31505754 http://dx.doi.org/10.3390/molecules24183277 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Theodosis-Nobelos, Panagiotis Papagiouvannis, Georgios Kourounakis, Panos N. Rekka, Eleni A. Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title | Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title_full | Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title_fullStr | Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title_full_unstemmed | Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title_short | Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam |
title_sort | active anti-inflammatory and hypolipidemic derivatives of lorazepam |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767220/ https://www.ncbi.nlm.nih.gov/pubmed/31505754 http://dx.doi.org/10.3390/molecules24183277 |
work_keys_str_mv | AT theodosisnobelospanagiotis activeantiinflammatoryandhypolipidemicderivativesoflorazepam AT papagiouvannisgeorgios activeantiinflammatoryandhypolipidemicderivativesoflorazepam AT kourounakispanosn activeantiinflammatoryandhypolipidemicderivativesoflorazepam AT rekkaelenia activeantiinflammatoryandhypolipidemicderivativesoflorazepam |