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Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam

Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivat...

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Autores principales: Theodosis-Nobelos, Panagiotis, Papagiouvannis, Georgios, Kourounakis, Panos N., Rekka, Eleni A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767220/
https://www.ncbi.nlm.nih.gov/pubmed/31505754
http://dx.doi.org/10.3390/molecules24183277
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author Theodosis-Nobelos, Panagiotis
Papagiouvannis, Georgios
Kourounakis, Panos N.
Rekka, Eleni A.
author_facet Theodosis-Nobelos, Panagiotis
Papagiouvannis, Georgios
Kourounakis, Panos N.
Rekka, Eleni A.
author_sort Theodosis-Nobelos, Panagiotis
collection PubMed
description Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress.
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spelling pubmed-67672202019-10-02 Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam Theodosis-Nobelos, Panagiotis Papagiouvannis, Georgios Kourounakis, Panos N. Rekka, Eleni A. Molecules Article Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress. MDPI 2019-09-09 /pmc/articles/PMC6767220/ /pubmed/31505754 http://dx.doi.org/10.3390/molecules24183277 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Theodosis-Nobelos, Panagiotis
Papagiouvannis, Georgios
Kourounakis, Panos N.
Rekka, Eleni A.
Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title_full Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title_fullStr Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title_full_unstemmed Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title_short Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam
title_sort active anti-inflammatory and hypolipidemic derivatives of lorazepam
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767220/
https://www.ncbi.nlm.nih.gov/pubmed/31505754
http://dx.doi.org/10.3390/molecules24183277
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