Cargando…

Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study

PURPOSE: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle‐aged Caucasians. METHODS: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (C...

Descripción completa

Detalles Bibliográficos
Autores principales: Geneid, Mohamed, Kettunen, Joonas, Nuuttila, Iida, Lintonen, Timo, Uusitalo, Janne‐Joonas, Saarela, Ville, Liinamaa, M. Johanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767424/
https://www.ncbi.nlm.nih.gov/pubmed/30537339
http://dx.doi.org/10.1111/aos.13992
_version_ 1783454914647687168
author Geneid, Mohamed
Kettunen, Joonas
Nuuttila, Iida
Lintonen, Timo
Uusitalo, Janne‐Joonas
Saarela, Ville
Liinamaa, M. Johanna
author_facet Geneid, Mohamed
Kettunen, Joonas
Nuuttila, Iida
Lintonen, Timo
Uusitalo, Janne‐Joonas
Saarela, Ville
Liinamaa, M. Johanna
author_sort Geneid, Mohamed
collection PubMed
description PURPOSE: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle‐aged Caucasians. METHODS: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi‐automated computer‐assisted program. Retinal nerve fibre layer (RNFL) thickness and ONH parameters were assessed with Heidelberg retinal tomography (HRT). RESULTS: Data from 2217 persons were analysed including RNFL, CRAE, CRVE, sex, body mass index, mean arterial pressure, diabetes status, smoking status, optic disc area, rim area, spherical refraction and intraocular pressure. A larger RVD was associated with a thicker mean global RNFL thickness especially in global and inferior segments of the retina and with larger optic discs. Each 10 μm increase in the retinal arteriolar calibre was associated with a 5.58 μm increase in mean global RNFL thickness; the corresponding value for a 10 μm increase in venular calibre was 3.79 μm (p < 0.001 for both). Retinal venular calibre displayed consistent associations with RNFL thickness in both genders (p < 0.001 for all), whereas the association of arteriolar calibre and RNFL was more prominent in men (p < 0.001). CONCLUSION: We found strong associations between larger RVD and thicker RNFL in all subjects. This study helps to clarify the association between RVD, RNFL thickness and ONH parameters and provides normal values for middle‐aged Caucasians that will help in future studies investigating the role of vascular aetiology in systemic and eye diseases.
format Online
Article
Text
id pubmed-6767424
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-67674242019-10-03 Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study Geneid, Mohamed Kettunen, Joonas Nuuttila, Iida Lintonen, Timo Uusitalo, Janne‐Joonas Saarela, Ville Liinamaa, M. Johanna Acta Ophthalmol Original Articles PURPOSE: To study the normal relationship between retinal vessel diameter (RVD) with retinal nerve fibre layer (RNFL) thickness and optic nerve head (ONH) parameters in a cohort of middle‐aged Caucasians. METHODS: We investigated 3070 individuals (6140 eyes). Central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) were measured in the right eye using a semi‐automated computer‐assisted program. Retinal nerve fibre layer (RNFL) thickness and ONH parameters were assessed with Heidelberg retinal tomography (HRT). RESULTS: Data from 2217 persons were analysed including RNFL, CRAE, CRVE, sex, body mass index, mean arterial pressure, diabetes status, smoking status, optic disc area, rim area, spherical refraction and intraocular pressure. A larger RVD was associated with a thicker mean global RNFL thickness especially in global and inferior segments of the retina and with larger optic discs. Each 10 μm increase in the retinal arteriolar calibre was associated with a 5.58 μm increase in mean global RNFL thickness; the corresponding value for a 10 μm increase in venular calibre was 3.79 μm (p < 0.001 for both). Retinal venular calibre displayed consistent associations with RNFL thickness in both genders (p < 0.001 for all), whereas the association of arteriolar calibre and RNFL was more prominent in men (p < 0.001). CONCLUSION: We found strong associations between larger RVD and thicker RNFL in all subjects. This study helps to clarify the association between RVD, RNFL thickness and ONH parameters and provides normal values for middle‐aged Caucasians that will help in future studies investigating the role of vascular aetiology in systemic and eye diseases. John Wiley and Sons Inc. 2018-12-10 2019-08 /pmc/articles/PMC6767424/ /pubmed/30537339 http://dx.doi.org/10.1111/aos.13992 Text en © 2018 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Geneid, Mohamed
Kettunen, Joonas
Nuuttila, Iida
Lintonen, Timo
Uusitalo, Janne‐Joonas
Saarela, Ville
Liinamaa, M. Johanna
Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title_full Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title_fullStr Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title_full_unstemmed Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title_short Relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged Caucasians: the Northern Finland Birth Cohort Eye study
title_sort relationship between retinal vessel diameter with both retinal nerve fibre layer thickness and optic nerve head parameters in middle‐aged caucasians: the northern finland birth cohort eye study
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767424/
https://www.ncbi.nlm.nih.gov/pubmed/30537339
http://dx.doi.org/10.1111/aos.13992
work_keys_str_mv AT geneidmohamed relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT kettunenjoonas relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT nuuttilaiida relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT lintonentimo relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT uusitalojannejoonas relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT saarelaville relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy
AT liinamaamjohanna relationshipbetweenretinalvesseldiameterwithbothretinalnervefibrelayerthicknessandopticnerveheadparametersinmiddleagedcaucasiansthenorthernfinlandbirthcohorteyestudy