Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature

MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a 62-year-old male with follicular lymphoma who had an MYD88 L265P somatic mutation and monoclonal IgM gammopath...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Linglong, Ding, Xiaoxiao, Ying, Limei, Zhang, Xiaochang, Lu, Nina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767481/
https://www.ncbi.nlm.nih.gov/pubmed/31576141
http://dx.doi.org/10.2147/OTT.S211436
_version_ 1783454927772712960
author Xu, Linglong
Ding, Xiaoxiao
Ying, Limei
Zhang, Xiaochang
Lu, Nina
author_facet Xu, Linglong
Ding, Xiaoxiao
Ying, Limei
Zhang, Xiaochang
Lu, Nina
author_sort Xu, Linglong
collection PubMed
description MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a 62-year-old male with follicular lymphoma who had an MYD88 L265P somatic mutation and monoclonal IgM gammopathy. He received four cycles of R-CHOP immunochemotherapy. Interim PET/CT evaluation indicated a state of stable disease (SD). Neither did serum IgM remarkably drop. He was then given a bortezomib-contained regimen which significantly reduced the level of serum IgM. To the best of our knowledge, this is the first report of follicular lymphoma with monoclonal IgM and MYD88 L265P mutation. The present case indicated bortezomib may benefit these patients.
format Online
Article
Text
id pubmed-6767481
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Dove
record_format MEDLINE/PubMed
spelling pubmed-67674812019-10-01 Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature Xu, Linglong Ding, Xiaoxiao Ying, Limei Zhang, Xiaochang Lu, Nina Onco Targets Ther Case Report MYD88 mutation has been reported in various lymphomas, specifically in lymphoplasmacytic lymphoma. Yet, the mutation has not been reported in primary follicular lymphoma. Here, we present a 62-year-old male with follicular lymphoma who had an MYD88 L265P somatic mutation and monoclonal IgM gammopathy. He received four cycles of R-CHOP immunochemotherapy. Interim PET/CT evaluation indicated a state of stable disease (SD). Neither did serum IgM remarkably drop. He was then given a bortezomib-contained regimen which significantly reduced the level of serum IgM. To the best of our knowledge, this is the first report of follicular lymphoma with monoclonal IgM and MYD88 L265P mutation. The present case indicated bortezomib may benefit these patients. Dove 2019-09-23 /pmc/articles/PMC6767481/ /pubmed/31576141 http://dx.doi.org/10.2147/OTT.S211436 Text en © 2019 Xu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Case Report
Xu, Linglong
Ding, Xiaoxiao
Ying, Limei
Zhang, Xiaochang
Lu, Nina
Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title_full Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title_fullStr Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title_full_unstemmed Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title_short Follicular Lymphoma Presenting With Monoclonal IgM And MYD88 Mutation: A Case Report And Review Of The Literature
title_sort follicular lymphoma presenting with monoclonal igm and myd88 mutation: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767481/
https://www.ncbi.nlm.nih.gov/pubmed/31576141
http://dx.doi.org/10.2147/OTT.S211436
work_keys_str_mv AT xulinglong follicularlymphomapresentingwithmonoclonaligmandmyd88mutationacasereportandreviewoftheliterature
AT dingxiaoxiao follicularlymphomapresentingwithmonoclonaligmandmyd88mutationacasereportandreviewoftheliterature
AT yinglimei follicularlymphomapresentingwithmonoclonaligmandmyd88mutationacasereportandreviewoftheliterature
AT zhangxiaochang follicularlymphomapresentingwithmonoclonaligmandmyd88mutationacasereportandreviewoftheliterature
AT lunina follicularlymphomapresentingwithmonoclonaligmandmyd88mutationacasereportandreviewoftheliterature

Ejemplares similares