Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load

The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicar...

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Autores principales: Kellert, Martin, Lönnecke, Peter, Riedl, Bernd, Koebberling, Johannes, Hey-Hawkins, Evamarie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767515/
https://www.ncbi.nlm.nih.gov/pubmed/31509949
http://dx.doi.org/10.3390/molecules24183288
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author Kellert, Martin
Lönnecke, Peter
Riedl, Bernd
Koebberling, Johannes
Hey-Hawkins, Evamarie
author_facet Kellert, Martin
Lönnecke, Peter
Riedl, Bernd
Koebberling, Johannes
Hey-Hawkins, Evamarie
author_sort Kellert, Martin
collection PubMed
description The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol.
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spelling pubmed-67675152019-10-02 Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load Kellert, Martin Lönnecke, Peter Riedl, Bernd Koebberling, Johannes Hey-Hawkins, Evamarie Molecules Article The amount of boron accumulated in tumor tissue plays an important role regarding the success of the boron neutron capture therapy (BNCT). In this article, we report a modular system, combining readily available starting materials, like glycine, 1,3,5-triazine and the well-known 9-mercapto-1,7-dicarba-closo-dodecaborane(12), as well as α-d-galactopyranose for increased hydrophilicity, with a novel boron-rich tris-meta-carboranyl thiol. MDPI 2019-09-10 /pmc/articles/PMC6767515/ /pubmed/31509949 http://dx.doi.org/10.3390/molecules24183288 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kellert, Martin
Lönnecke, Peter
Riedl, Bernd
Koebberling, Johannes
Hey-Hawkins, Evamarie
Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_full Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_fullStr Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_full_unstemmed Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_short Enlargement of a Modular System—Synthesis and Characterization of an s-Triazine-Based Carboxylic Acid Ester Bearing a Galactopyranosyl Moiety and an Enormous Boron Load
title_sort enlargement of a modular system—synthesis and characterization of an s-triazine-based carboxylic acid ester bearing a galactopyranosyl moiety and an enormous boron load
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767515/
https://www.ncbi.nlm.nih.gov/pubmed/31509949
http://dx.doi.org/10.3390/molecules24183288
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