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Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes
AIM: To quantify the risk of different non‐invasive arterial stiffness measurements with macrovascular disease and all‐cause mortality in high‐risk people with Type 2 diabetes. METHODS: We conducted a prospective cohort study of 1910 people with Type 2 diabetes included in the Second Manifestations...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767543/ https://www.ncbi.nlm.nih.gov/pubmed/30920676 http://dx.doi.org/10.1111/dme.13954 |
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author | Sharif, S. Visseren, F. L. J. Spiering, W. de Jong, P. A. Bots, M. L. Westerink, J. |
author_facet | Sharif, S. Visseren, F. L. J. Spiering, W. de Jong, P. A. Bots, M. L. Westerink, J. |
author_sort | Sharif, S. |
collection | PubMed |
description | AIM: To quantify the risk of different non‐invasive arterial stiffness measurements with macrovascular disease and all‐cause mortality in high‐risk people with Type 2 diabetes. METHODS: We conducted a prospective cohort study of 1910 people with Type 2 diabetes included in the Second Manifestations of ARTerial disease (SMART) study. Arterial stiffness was assessed by brachial artery pulse pressure, normal range (≥0.9) ankle–brachial index and carotid artery distension. Cox regression was used to evaluate the effects of arterial stiffness on risk of cardiovascular events (composite of myocardial infarction, stroke and vascular mortality) and all‐cause mortality. RESULTS: A total of 380 new cardiovascular events and 436 deaths occurred during a median (interquartile range) follow‐up of 7.5 (4.1–11.0) years. A 10‐mmHg higher brachial pulse pressure was related to higher hazard of cardiovascular events (hazard ratio 1.09, 95% CI 1.02 to 1.16) and all‐cause mortality (hazard ratio 1.10, 95% CI 1.03 to 1.16). A 0.1‐point lower ankle–brachial index within the normal range was related to a higher hazard of cardiovascular events (hazard ratio 1.13, 95% CI 1.01 to 1.27) and all‐cause mortality (hazard ratio 1.17, 95% CI 1.04 to 1.31). A one‐unit (10(−3)×kPa(−1)) lower carotid artery distensibility coefficient was related to a higher hazard of vascular mortality (hazard ratio 1.04, 95% CI 1.00 to 1.09) and all‐cause mortality (hazard ratio 1.04, 95% CI 1.00 to 1.07). CONCLUSION: Increased arterial stiffness, as measured by either increased pulse pressure, normal‐range ankle–brachial index or carotid artery distensibility coefficient, is related to increased hazard of cardiovascular events and all‐cause mortality in people with Type 2 diabetes. |
format | Online Article Text |
id | pubmed-6767543 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67675432019-10-03 Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes Sharif, S. Visseren, F. L. J. Spiering, W. de Jong, P. A. Bots, M. L. Westerink, J. Diabet Med Research Articles AIM: To quantify the risk of different non‐invasive arterial stiffness measurements with macrovascular disease and all‐cause mortality in high‐risk people with Type 2 diabetes. METHODS: We conducted a prospective cohort study of 1910 people with Type 2 diabetes included in the Second Manifestations of ARTerial disease (SMART) study. Arterial stiffness was assessed by brachial artery pulse pressure, normal range (≥0.9) ankle–brachial index and carotid artery distension. Cox regression was used to evaluate the effects of arterial stiffness on risk of cardiovascular events (composite of myocardial infarction, stroke and vascular mortality) and all‐cause mortality. RESULTS: A total of 380 new cardiovascular events and 436 deaths occurred during a median (interquartile range) follow‐up of 7.5 (4.1–11.0) years. A 10‐mmHg higher brachial pulse pressure was related to higher hazard of cardiovascular events (hazard ratio 1.09, 95% CI 1.02 to 1.16) and all‐cause mortality (hazard ratio 1.10, 95% CI 1.03 to 1.16). A 0.1‐point lower ankle–brachial index within the normal range was related to a higher hazard of cardiovascular events (hazard ratio 1.13, 95% CI 1.01 to 1.27) and all‐cause mortality (hazard ratio 1.17, 95% CI 1.04 to 1.31). A one‐unit (10(−3)×kPa(−1)) lower carotid artery distensibility coefficient was related to a higher hazard of vascular mortality (hazard ratio 1.04, 95% CI 1.00 to 1.09) and all‐cause mortality (hazard ratio 1.04, 95% CI 1.00 to 1.07). CONCLUSION: Increased arterial stiffness, as measured by either increased pulse pressure, normal‐range ankle–brachial index or carotid artery distensibility coefficient, is related to increased hazard of cardiovascular events and all‐cause mortality in people with Type 2 diabetes. John Wiley and Sons Inc. 2019-04-15 2019-09 /pmc/articles/PMC6767543/ /pubmed/30920676 http://dx.doi.org/10.1111/dme.13954 Text en © 2019 The Authors. Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Sharif, S. Visseren, F. L. J. Spiering, W. de Jong, P. A. Bots, M. L. Westerink, J. Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title | Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title_full | Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title_fullStr | Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title_full_unstemmed | Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title_short | Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes |
title_sort | arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with type 2 diabetes |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767543/ https://www.ncbi.nlm.nih.gov/pubmed/30920676 http://dx.doi.org/10.1111/dme.13954 |
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