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Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation

PURPOSE: To accelerate (19)F‐MR imaging of inhaled perfluoropropane using compressed sensing methods, and to optimize critical scan acquisition parameters for assessment of lung ventilation properties. METHODS: Simulations were performed to determine optimal acquisition parameters for maximal perflu...

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Autores principales: Neal, Mary A., Pippard, Benjamin J., Hollingsworth, Kieren G., Maunder, Adam, Dutta, Prosenjit, Simpson, A. John, Blamire, Andrew M., Wild, James M., Thelwall, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767591/
https://www.ncbi.nlm.nih.gov/pubmed/31099437
http://dx.doi.org/10.1002/mrm.27805
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author Neal, Mary A.
Pippard, Benjamin J.
Hollingsworth, Kieren G.
Maunder, Adam
Dutta, Prosenjit
Simpson, A. John
Blamire, Andrew M.
Wild, James M.
Thelwall, Peter E.
author_facet Neal, Mary A.
Pippard, Benjamin J.
Hollingsworth, Kieren G.
Maunder, Adam
Dutta, Prosenjit
Simpson, A. John
Blamire, Andrew M.
Wild, James M.
Thelwall, Peter E.
author_sort Neal, Mary A.
collection PubMed
description PURPOSE: To accelerate (19)F‐MR imaging of inhaled perfluoropropane using compressed sensing methods, and to optimize critical scan acquisition parameters for assessment of lung ventilation properties. METHODS: Simulations were performed to determine optimal acquisition parameters for maximal perfluoropropane signal‐to‐noise ratio (SNR) in human lungs for a spoiled gradient echo sequence. Optimized parameters were subsequently employed for (19)F‐MRI of inhaled perfluoropropane in a cohort of 11 healthy participants using a 3.0 T scanner. The impact of 1.8×, 2.4×, and 3.0× undersampling ratios on (19)F‐MRI acquisitions was evaluated, using both retrospective and prospective compressed sensing methods. RESULTS: 3D spoiled gradient echo (19)F‐MR ventilation images were acquired at 1‐cm isotropic resolution within a single breath hold. Mean SNR was 11.7 ± 4.1 for scans acquired within a single breath hold (duration = 18 s). Acquisition of (19)F‐MRI scans at shorter scan durations (4.5 s) was also demonstrated as feasible. Application of both retrospective (n = 8) and prospective (n = 3) compressed sensing methods demonstrated that 1.8× acceleration had negligible impact on qualitative image appearance, with no statistically significant change in measured lung ventilated volume. Acceleration factors of 2.4× and 3.0× resulted in increasing differences between fully sampled and undersampled datasets. CONCLUSION: This study demonstrates methods for determining optimal acquisition parameters for (19)F‐MRI of inhaled perfluoropropane and shows significant reduction in scan acquisition times (and thus participant breath hold duration) by use of compressed sensing.
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spelling pubmed-67675912019-10-03 Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation Neal, Mary A. Pippard, Benjamin J. Hollingsworth, Kieren G. Maunder, Adam Dutta, Prosenjit Simpson, A. John Blamire, Andrew M. Wild, James M. Thelwall, Peter E. Magn Reson Med Full Papers—Imaging Methodology PURPOSE: To accelerate (19)F‐MR imaging of inhaled perfluoropropane using compressed sensing methods, and to optimize critical scan acquisition parameters for assessment of lung ventilation properties. METHODS: Simulations were performed to determine optimal acquisition parameters for maximal perfluoropropane signal‐to‐noise ratio (SNR) in human lungs for a spoiled gradient echo sequence. Optimized parameters were subsequently employed for (19)F‐MRI of inhaled perfluoropropane in a cohort of 11 healthy participants using a 3.0 T scanner. The impact of 1.8×, 2.4×, and 3.0× undersampling ratios on (19)F‐MRI acquisitions was evaluated, using both retrospective and prospective compressed sensing methods. RESULTS: 3D spoiled gradient echo (19)F‐MR ventilation images were acquired at 1‐cm isotropic resolution within a single breath hold. Mean SNR was 11.7 ± 4.1 for scans acquired within a single breath hold (duration = 18 s). Acquisition of (19)F‐MRI scans at shorter scan durations (4.5 s) was also demonstrated as feasible. Application of both retrospective (n = 8) and prospective (n = 3) compressed sensing methods demonstrated that 1.8× acceleration had negligible impact on qualitative image appearance, with no statistically significant change in measured lung ventilated volume. Acceleration factors of 2.4× and 3.0× resulted in increasing differences between fully sampled and undersampled datasets. CONCLUSION: This study demonstrates methods for determining optimal acquisition parameters for (19)F‐MRI of inhaled perfluoropropane and shows significant reduction in scan acquisition times (and thus participant breath hold duration) by use of compressed sensing. John Wiley and Sons Inc. 2019-05-17 2019-10 /pmc/articles/PMC6767591/ /pubmed/31099437 http://dx.doi.org/10.1002/mrm.27805 Text en © 2019 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers—Imaging Methodology
Neal, Mary A.
Pippard, Benjamin J.
Hollingsworth, Kieren G.
Maunder, Adam
Dutta, Prosenjit
Simpson, A. John
Blamire, Andrew M.
Wild, James M.
Thelwall, Peter E.
Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title_full Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title_fullStr Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title_full_unstemmed Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title_short Optimized and accelerated (19)F‐MRI of inhaled perfluoropropane to assess regional pulmonary ventilation
title_sort optimized and accelerated (19)f‐mri of inhaled perfluoropropane to assess regional pulmonary ventilation
topic Full Papers—Imaging Methodology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767591/
https://www.ncbi.nlm.nih.gov/pubmed/31099437
http://dx.doi.org/10.1002/mrm.27805
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