Optimization of Preparation and Preclinical Pharmacokinetics of Celastrol-Encapsulated Silk Fibroin Nanoparticles in the Rat

Celastrol (CL), a bioactive compound isolated from Tripterygium wilfordii, has demonstrated bioactivities against a variety of diseases including cancer and obesity. However, its poor water solubility and rapid in vivo clearance limit its clinical applications. To overcome these limitations, nanotec...

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Detalles Bibliográficos
Autores principales: Onyeabor, Felicia, Paik, Amy, Kovvasu, Surya, Ding, Baoyue, Lin, Jelissa, Wahid, Md Arif, Prabhu, Sunil, Betageri, Guru, Wang, Jeffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767603/
https://www.ncbi.nlm.nih.gov/pubmed/31500392
http://dx.doi.org/10.3390/molecules24183271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767603/
https://www.ncbi.nlm.nih.gov/pubmed/31500392
http://dx.doi.org/10.3390/molecules24183271

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