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Metabolic engineering with ATP-citrate lyase and nitrogen source supplementation improves itaconic acid production in Aspergillus niger

BACKGROUND: Bio-based production of organic acids promises to be an attractive alternative for the chemicals industry to substitute petrochemicals as building-block chemicals. In recent years, itaconic acid (IA, methylenesuccinic acid) has been established as a sustainable building-block chemical fo...

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Detalles Bibliográficos
Autores principales: Hossain, Abeer H., van Gerven, Roy, Overkamp, Karin M., Lübeck, Peter S., Taşpınar, Hatice, Türker, Mustafa, Punt, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767652/
https://www.ncbi.nlm.nih.gov/pubmed/31583019
http://dx.doi.org/10.1186/s13068-019-1577-6