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Ferrogels Ultrasonography for Biomedical Applications

Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG s...

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Autores principales: Blyakhman, Felix A., Sokolov, Sergey Yu, Safronov, Alexander P., Dinislamova, Olga A., Shklyar, Tatyana F., Zubarev, Andrey Yu, Kurlyandskaya, Galina V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767681/
https://www.ncbi.nlm.nih.gov/pubmed/31540284
http://dx.doi.org/10.3390/s19183959
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author Blyakhman, Felix A.
Sokolov, Sergey Yu
Safronov, Alexander P.
Dinislamova, Olga A.
Shklyar, Tatyana F.
Zubarev, Andrey Yu
Kurlyandskaya, Galina V.
author_facet Blyakhman, Felix A.
Sokolov, Sergey Yu
Safronov, Alexander P.
Dinislamova, Olga A.
Shklyar, Tatyana F.
Zubarev, Andrey Yu
Kurlyandskaya, Galina V.
author_sort Blyakhman, Felix A.
collection PubMed
description Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction.
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spelling pubmed-67676812019-10-02 Ferrogels Ultrasonography for Biomedical Applications Blyakhman, Felix A. Sokolov, Sergey Yu Safronov, Alexander P. Dinislamova, Olga A. Shklyar, Tatyana F. Zubarev, Andrey Yu Kurlyandskaya, Galina V. Sensors (Basel) Article Ferrogels (FG) are magnetic composites that are widely used in the area of biomedical engineering and biosensing. In this work, ferrogels with different concentrations of magnetic nanoparticles (MNPs) were synthesized by the radical polymerization of acrylamide in stabilized aqueous ferrofluid. FG samples were prepared in various shapes that are suitable for different characterization techniques. Thin cylindrical samples were used to simulate the case of targeted drug delivery test through blood vessels. Samples of larger size that were in the shape of cylindrical plates were used for the evaluation of the FG applicability as substitutes for damaged structures, such as bone or cartilage tissues. Regardless of the shape of the samples and the conditions of their location, the boundaries of FG were confidently visualized over the entire range of concentrations of MNPs while using medical ultrasound. The amplitude of the reflected echo signal was higher for the higher concentration of MNPs in the gel. This result was not related to the influence of the MNPs on the intensity of the reflected echo signal directly, since the wavelength of the ultrasonic effect used is much larger than the particle size. Qualitative theoretical model for the understanding of the experimental results was proposed while taking into account the concept that at the acoustic oscillations of the hydrogel, the macromolecular net, and water in the gel porous structure experience the viscous Stocks-like interaction. MDPI 2019-09-13 /pmc/articles/PMC6767681/ /pubmed/31540284 http://dx.doi.org/10.3390/s19183959 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Blyakhman, Felix A.
Sokolov, Sergey Yu
Safronov, Alexander P.
Dinislamova, Olga A.
Shklyar, Tatyana F.
Zubarev, Andrey Yu
Kurlyandskaya, Galina V.
Ferrogels Ultrasonography for Biomedical Applications
title Ferrogels Ultrasonography for Biomedical Applications
title_full Ferrogels Ultrasonography for Biomedical Applications
title_fullStr Ferrogels Ultrasonography for Biomedical Applications
title_full_unstemmed Ferrogels Ultrasonography for Biomedical Applications
title_short Ferrogels Ultrasonography for Biomedical Applications
title_sort ferrogels ultrasonography for biomedical applications
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767681/
https://www.ncbi.nlm.nih.gov/pubmed/31540284
http://dx.doi.org/10.3390/s19183959
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