Dynamic clamping human and rabbit atrial calcium current: narrowing I (CaL) window abolishes early afterdepolarizations

KEY POINTS: Early‐afterdepolarizations (EADs) are abnormal action potential oscillations and a known cause of cardiac arrhythmias. Ventricular EADs involve reactivation of a Ca(2+) current (I (CaL)) in its ‘window region’ voltage range. However, electrical mechanisms of atrial EADs, a potential caus...

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Detalles Bibliográficos
Autores principales: Kettlewell, Sarah, Saxena, Priyanka, Dempster, John, Colman, Michael A., Myles, Rachel C., Smith, Godfrey L., Workman, Antony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Cardiovascular
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767690/
https://www.ncbi.nlm.nih.gov/pubmed/31093979
http://dx.doi.org/10.1113/JP277827

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