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Schizophrenia and bipolar disorders: The Toxoplasma connection

The infectious etiology of psychiatric illnesses has remained an unexplored area till recently. During the past two decades, numerous studies from multiple angles have tried to link chronic toxoplasmosis with schizophrenia and bipolar disorders, among others. Most of the evidence has come from serol...

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Detalles Bibliográficos
Autores principales: Chaudhury, Abhijit, Ramana, B. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767789/
https://www.ncbi.nlm.nih.gov/pubmed/31579659
http://dx.doi.org/10.4103/tp.TP_28_19
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author Chaudhury, Abhijit
Ramana, B. V.
author_facet Chaudhury, Abhijit
Ramana, B. V.
author_sort Chaudhury, Abhijit
collection PubMed
description The infectious etiology of psychiatric illnesses has remained an unexplored area till recently. During the past two decades, numerous studies from multiple angles have tried to link chronic toxoplasmosis with schizophrenia and bipolar disorders, among others. Most of the evidence has come from serological studies in the patient population, but other facets have also been explored. This review examines the various areas from which a causal link has been deduced and includes: (a) serological studies, (b) effect of maternal toxoplasmosis on children, (c) neurotransmitter studies, (d) parasite localization in the brain, (e) role of cytokines, and (f) psychotherapy and its effect on Toxoplasma. However, multiple factors may play a role in the etiopathogenesis of psychiatric illnesses, and chronic Toxoplasma infection may be considered an important risk factor for the genesis and symptomatology of schizophrenia and bipolar disorders.
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spelling pubmed-67677892019-10-02 Schizophrenia and bipolar disorders: The Toxoplasma connection Chaudhury, Abhijit Ramana, B. V. Trop Parasitol Review Article The infectious etiology of psychiatric illnesses has remained an unexplored area till recently. During the past two decades, numerous studies from multiple angles have tried to link chronic toxoplasmosis with schizophrenia and bipolar disorders, among others. Most of the evidence has come from serological studies in the patient population, but other facets have also been explored. This review examines the various areas from which a causal link has been deduced and includes: (a) serological studies, (b) effect of maternal toxoplasmosis on children, (c) neurotransmitter studies, (d) parasite localization in the brain, (e) role of cytokines, and (f) psychotherapy and its effect on Toxoplasma. However, multiple factors may play a role in the etiopathogenesis of psychiatric illnesses, and chronic Toxoplasma infection may be considered an important risk factor for the genesis and symptomatology of schizophrenia and bipolar disorders. Wolters Kluwer - Medknow 2019 2019-09-18 /pmc/articles/PMC6767789/ /pubmed/31579659 http://dx.doi.org/10.4103/tp.TP_28_19 Text en Copyright: © 2019 Tropical Parasitology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review Article
Chaudhury, Abhijit
Ramana, B. V.
Schizophrenia and bipolar disorders: The Toxoplasma connection
title Schizophrenia and bipolar disorders: The Toxoplasma connection
title_full Schizophrenia and bipolar disorders: The Toxoplasma connection
title_fullStr Schizophrenia and bipolar disorders: The Toxoplasma connection
title_full_unstemmed Schizophrenia and bipolar disorders: The Toxoplasma connection
title_short Schizophrenia and bipolar disorders: The Toxoplasma connection
title_sort schizophrenia and bipolar disorders: the toxoplasma connection
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767789/
https://www.ncbi.nlm.nih.gov/pubmed/31579659
http://dx.doi.org/10.4103/tp.TP_28_19
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