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Evolutionary origins and impacts of genome architecture in ciliates
Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon‐rich genomes common among plants). In ciliates, a group of microbial eukaryotes with...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767857/ https://www.ncbi.nlm.nih.gov/pubmed/31074010 http://dx.doi.org/10.1111/nyas.14108 |
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author | Maurer‐Alcalá, Xyrus X. Nowacki, Mariusz |
author_facet | Maurer‐Alcalá, Xyrus X. Nowacki, Mariusz |
author_sort | Maurer‐Alcalá, Xyrus X. |
collection | PubMed |
description | Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon‐rich genomes common among plants). In ciliates, a group of microbial eukaryotes with distinct somatic and germ‐line genomes present in a single cell, the consequences of these genome conflicts are most apparent in their developmentally programmed genome rearrangements. This complicated developmental phenomenon has largely overshadowed and outpaced our understanding of how germ‐line and somatic genome architectures have influenced the evolutionary dynamism and potential in these taxa. In our review, we highlight three central concepts: how the evolution of atypical ciliate germ‐line genome architectures is linked to ancient genome conflicts; how the complex, epigenetically guided transformation of germline to soma during development can generate widespread genetic variation; and how these features, coupled with their unusual life cycle, have increased the rate of molecular evolution linked to genome architecture in these taxa. |
format | Online Article Text |
id | pubmed-6767857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67678572019-10-03 Evolutionary origins and impacts of genome architecture in ciliates Maurer‐Alcalá, Xyrus X. Nowacki, Mariusz Ann N Y Acad Sci Reviews Genome architecture is well diversified among eukaryotes in terms of size and content, with many being radically shaped by ancient and ongoing genome conflicts with transposable elements (e.g., the large transposon‐rich genomes common among plants). In ciliates, a group of microbial eukaryotes with distinct somatic and germ‐line genomes present in a single cell, the consequences of these genome conflicts are most apparent in their developmentally programmed genome rearrangements. This complicated developmental phenomenon has largely overshadowed and outpaced our understanding of how germ‐line and somatic genome architectures have influenced the evolutionary dynamism and potential in these taxa. In our review, we highlight three central concepts: how the evolution of atypical ciliate germ‐line genome architectures is linked to ancient genome conflicts; how the complex, epigenetically guided transformation of germline to soma during development can generate widespread genetic variation; and how these features, coupled with their unusual life cycle, have increased the rate of molecular evolution linked to genome architecture in these taxa. John Wiley and Sons Inc. 2019-05-10 2019-07 /pmc/articles/PMC6767857/ /pubmed/31074010 http://dx.doi.org/10.1111/nyas.14108 Text en © 2019 The Authors.Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Reviews Maurer‐Alcalá, Xyrus X. Nowacki, Mariusz Evolutionary origins and impacts of genome architecture in ciliates |
title | Evolutionary origins and impacts of genome architecture in ciliates |
title_full | Evolutionary origins and impacts of genome architecture in ciliates |
title_fullStr | Evolutionary origins and impacts of genome architecture in ciliates |
title_full_unstemmed | Evolutionary origins and impacts of genome architecture in ciliates |
title_short | Evolutionary origins and impacts of genome architecture in ciliates |
title_sort | evolutionary origins and impacts of genome architecture in ciliates |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767857/ https://www.ncbi.nlm.nih.gov/pubmed/31074010 http://dx.doi.org/10.1111/nyas.14108 |
work_keys_str_mv | AT maureralcalaxyrusx evolutionaryoriginsandimpactsofgenomearchitectureinciliates AT nowackimariusz evolutionaryoriginsandimpactsofgenomearchitectureinciliates |