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Cells Involved in Urethral Tissue Engineering: Systematic Review

The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The oc...

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Detalles Bibliográficos
Autores principales: Culenova, Martina, Ziaran, Stanislav, Danisovic, Lubos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767881/
https://www.ncbi.nlm.nih.gov/pubmed/31237144
http://dx.doi.org/10.1177/0963689719854363
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author Culenova, Martina
Ziaran, Stanislav
Danisovic, Lubos
author_facet Culenova, Martina
Ziaran, Stanislav
Danisovic, Lubos
author_sort Culenova, Martina
collection PubMed
description The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches.
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spelling pubmed-67678812019-10-18 Cells Involved in Urethral Tissue Engineering: Systematic Review Culenova, Martina Ziaran, Stanislav Danisovic, Lubos Cell Transplant Reviews The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches. SAGE Publications 2019-06-25 2019-09 /pmc/articles/PMC6767881/ /pubmed/31237144 http://dx.doi.org/10.1177/0963689719854363 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Reviews
Culenova, Martina
Ziaran, Stanislav
Danisovic, Lubos
Cells Involved in Urethral Tissue Engineering: Systematic Review
title Cells Involved in Urethral Tissue Engineering: Systematic Review
title_full Cells Involved in Urethral Tissue Engineering: Systematic Review
title_fullStr Cells Involved in Urethral Tissue Engineering: Systematic Review
title_full_unstemmed Cells Involved in Urethral Tissue Engineering: Systematic Review
title_short Cells Involved in Urethral Tissue Engineering: Systematic Review
title_sort cells involved in urethral tissue engineering: systematic review
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767881/
https://www.ncbi.nlm.nih.gov/pubmed/31237144
http://dx.doi.org/10.1177/0963689719854363
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