Cargando…
Cells Involved in Urethral Tissue Engineering: Systematic Review
The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The oc...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767881/ https://www.ncbi.nlm.nih.gov/pubmed/31237144 http://dx.doi.org/10.1177/0963689719854363 |
_version_ | 1783455015460929536 |
---|---|
author | Culenova, Martina Ziaran, Stanislav Danisovic, Lubos |
author_facet | Culenova, Martina Ziaran, Stanislav Danisovic, Lubos |
author_sort | Culenova, Martina |
collection | PubMed |
description | The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches. |
format | Online Article Text |
id | pubmed-6767881 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67678812019-10-18 Cells Involved in Urethral Tissue Engineering: Systematic Review Culenova, Martina Ziaran, Stanislav Danisovic, Lubos Cell Transplant Reviews The urethra is part of the lower urinary tract and its main role is urine voiding. Its complex histological structure makes urethral tissue prone to various injuries with complicated healing processes that often lead to scar formation. Urethral stricture disease can affect both men and women. The occurrence of this pathology is more common in men and thus are previous research has been mainly oriented on male urethra reconstruction. However, commonly used surgical techniques show unsatisfactory results because of complications. The new and progressively developing field of tissue engineering offers promising solutions, which could be applied in the urethral regeneration of both men´s and women´s urethras. The presented systematic review article offers an overview of the cells that have been used in urethral tissue engineering so far. Urine-derived stem cells show a great perspective in respect to urethral tissue engineering. They can be easily harvested and are a promising autologous cell source for the needs of tissue engineering techniques. The presented review also shows the importance of mechanical stimuli application on maturating tissue. Sufficient vascularization and elimination of stricture formation present the biggest challenges not only in customary surgical management but also in tissue-engineering approaches. SAGE Publications 2019-06-25 2019-09 /pmc/articles/PMC6767881/ /pubmed/31237144 http://dx.doi.org/10.1177/0963689719854363 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Reviews Culenova, Martina Ziaran, Stanislav Danisovic, Lubos Cells Involved in Urethral Tissue Engineering: Systematic Review |
title | Cells Involved in Urethral Tissue Engineering: Systematic
Review |
title_full | Cells Involved in Urethral Tissue Engineering: Systematic
Review |
title_fullStr | Cells Involved in Urethral Tissue Engineering: Systematic
Review |
title_full_unstemmed | Cells Involved in Urethral Tissue Engineering: Systematic
Review |
title_short | Cells Involved in Urethral Tissue Engineering: Systematic
Review |
title_sort | cells involved in urethral tissue engineering: systematic
review |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767881/ https://www.ncbi.nlm.nih.gov/pubmed/31237144 http://dx.doi.org/10.1177/0963689719854363 |
work_keys_str_mv | AT culenovamartina cellsinvolvedinurethraltissueengineeringsystematicreview AT ziaranstanislav cellsinvolvedinurethraltissueengineeringsystematicreview AT danisoviclubos cellsinvolvedinurethraltissueengineeringsystematicreview |