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Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke
Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767884/ https://www.ncbi.nlm.nih.gov/pubmed/31161782 http://dx.doi.org/10.1177/0963689719854342 |
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author | Sibov, Tatiana Taís Pavon, Lorena Favaro Cabral, Francisco Romero Cunha, Ivone Farias de Oliveira, Daniela Mara de Souza, Jean Gabriel Marti, Luciana Cavalheiro da Cruz, Edgar Ferreira Malheiros, Jackeline Moraes Paiva, Fernando F. Tannús, Alberto de Oliveira, Sérgio Mascarenhas da Costa, Marcos Devanir Silva Dastoli, Patrícia A. Mendonça, Jardel N. de Toledo, Silvia Regina Caminada Malheiros, Suzana M. Fleury de Paiva Neto, Manoel Antonio Rego, Nelma Bastos Bezerra Moron, Antônio Fernandes Cavalheiro, Sérgio |
author_facet | Sibov, Tatiana Taís Pavon, Lorena Favaro Cabral, Francisco Romero Cunha, Ivone Farias de Oliveira, Daniela Mara de Souza, Jean Gabriel Marti, Luciana Cavalheiro da Cruz, Edgar Ferreira Malheiros, Jackeline Moraes Paiva, Fernando F. Tannús, Alberto de Oliveira, Sérgio Mascarenhas da Costa, Marcos Devanir Silva Dastoli, Patrícia A. Mendonça, Jardel N. de Toledo, Silvia Regina Caminada Malheiros, Suzana M. Fleury de Paiva Neto, Manoel Antonio Rego, Nelma Bastos Bezerra Moron, Antônio Fernandes Cavalheiro, Sérgio |
author_sort | Sibov, Tatiana Taís |
collection | PubMed |
description | Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days after receiving cellular therapy via tail vein. In our animal model of stroke, transplanted cells migrated to the ischemic focus, infarct volume decreased, and motor deficits improved. Therefore, we concluded that these cells appear to have beneficial effects on the ischemic brain, possibly based on their ability to enhance endogenous repair mechanisms. |
format | Online Article Text |
id | pubmed-6767884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-67678842019-10-18 Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke Sibov, Tatiana Taís Pavon, Lorena Favaro Cabral, Francisco Romero Cunha, Ivone Farias de Oliveira, Daniela Mara de Souza, Jean Gabriel Marti, Luciana Cavalheiro da Cruz, Edgar Ferreira Malheiros, Jackeline Moraes Paiva, Fernando F. Tannús, Alberto de Oliveira, Sérgio Mascarenhas da Costa, Marcos Devanir Silva Dastoli, Patrícia A. Mendonça, Jardel N. de Toledo, Silvia Regina Caminada Malheiros, Suzana M. Fleury de Paiva Neto, Manoel Antonio Rego, Nelma Bastos Bezerra Moron, Antônio Fernandes Cavalheiro, Sérgio Cell Transplant Original Articles Amniotic fluid has been investigated as new cell source for stem cells in the development of future cell-based transplantation. This study reports isolation of viable human amniotic fluid-derived stem cells, labeled with multimodal iron oxide nanoparticles, and its effect on focal cerebral ischemia–reperfusion injury in Wistar rats. Middle cerebral artery occlusion of 60 min followed by reperfusion for 1 h, 6 h, and 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in rats. Tests were employed to assess the functional outcome of the sensorimotor center activity in the brain, through a set of modified neurological severity scores used to assess motor and exploratory capacity 24 h, 14, and 28 days after receiving cellular therapy via tail vein. In our animal model of stroke, transplanted cells migrated to the ischemic focus, infarct volume decreased, and motor deficits improved. Therefore, we concluded that these cells appear to have beneficial effects on the ischemic brain, possibly based on their ability to enhance endogenous repair mechanisms. SAGE Publications 2019-06-04 2019-09 /pmc/articles/PMC6767884/ /pubmed/31161782 http://dx.doi.org/10.1177/0963689719854342 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Sibov, Tatiana Taís Pavon, Lorena Favaro Cabral, Francisco Romero Cunha, Ivone Farias de Oliveira, Daniela Mara de Souza, Jean Gabriel Marti, Luciana Cavalheiro da Cruz, Edgar Ferreira Malheiros, Jackeline Moraes Paiva, Fernando F. Tannús, Alberto de Oliveira, Sérgio Mascarenhas da Costa, Marcos Devanir Silva Dastoli, Patrícia A. Mendonça, Jardel N. de Toledo, Silvia Regina Caminada Malheiros, Suzana M. Fleury de Paiva Neto, Manoel Antonio Rego, Nelma Bastos Bezerra Moron, Antônio Fernandes Cavalheiro, Sérgio Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce Behavioral Deficits in Experimental Ischemic Stroke |
title | Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
Behavioral Deficits in Experimental Ischemic Stroke |
title_full | Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
Behavioral Deficits in Experimental Ischemic Stroke |
title_fullStr | Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
Behavioral Deficits in Experimental Ischemic Stroke |
title_full_unstemmed | Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
Behavioral Deficits in Experimental Ischemic Stroke |
title_short | Intravenous Grafts of Human Amniotic Fluid-Derived Stem Cells Reduce
Behavioral Deficits in Experimental Ischemic Stroke |
title_sort | intravenous grafts of human amniotic fluid-derived stem cells reduce
behavioral deficits in experimental ischemic stroke |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767884/ https://www.ncbi.nlm.nih.gov/pubmed/31161782 http://dx.doi.org/10.1177/0963689719854342 |
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