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A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment

Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports h...

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Autores principales: Pantos, Konstantinos, Simopoulou, Mara, Pantou, Agni, Rapani, Anna, Tsioulou, Petroula, Nitsos, Nikolaos, Syrkos, Stephen, Pappas, Athanasios, Koutsilieris, Michael, Sfakianoudis, Konstantinos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767896/
https://www.ncbi.nlm.nih.gov/pubmed/31271054
http://dx.doi.org/10.1177/0963689719859539
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author Pantos, Konstantinos
Simopoulou, Mara
Pantou, Agni
Rapani, Anna
Tsioulou, Petroula
Nitsos, Nikolaos
Syrkos, Stephen
Pappas, Athanasios
Koutsilieris, Michael
Sfakianoudis, Konstantinos
author_facet Pantos, Konstantinos
Simopoulou, Mara
Pantou, Agni
Rapani, Anna
Tsioulou, Petroula
Nitsos, Nikolaos
Syrkos, Stephen
Pappas, Athanasios
Koutsilieris, Michael
Sfakianoudis, Konstantinos
author_sort Pantos, Konstantinos
collection PubMed
description Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2–6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies – a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause.
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spelling pubmed-67678962019-10-18 A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment Pantos, Konstantinos Simopoulou, Mara Pantou, Agni Rapani, Anna Tsioulou, Petroula Nitsos, Nikolaos Syrkos, Stephen Pappas, Athanasios Koutsilieris, Michael Sfakianoudis, Konstantinos Cell Transplant Case Study Since the introduction of autologous platelet-rich plasma (PRP) in medical practice, various studies have documented that implementing PRP can enhance healing and the anti-aging process, employing angiogenesis regeneration due to the multiple growth factors and cytokines involved. Numerous reports have shown promising results with the use of PRP in ovarian treatment, regarding ovarian regeneration and reactivation of folliculogenesis. This case series reports on two women with premature ovarian failure (POF) aged 40 and 27 years, respectively, and one menopausal woman aged 46 years. All patients presented with lack of menstrual cycle for over a year. The women reported previous failed in vitro fertilization (IVF) attempts, and, after rejecting the option of oocyte donation, they opted for the approach of autologous ovarian PRP treatment. Following PRP treatment, the three patients were invited to conceive naturally. The primary outcome was the restoration of menstruation following autologous ovarian PRP treatment, as well as an improvement in hormonal profile, a decrease in follicle-stimulating hormone (FSH) levels, and a concurrent increase in anti-Müllerian hormone (AMH) levels. Further to that, our patients achieved pregnancy through natural conception within 2–6 months following PRP treatment, resulting in currently ongoing complication-free clinical pregnancies – a first report in the literature for menopausal and POF patients. Implementation of PRP should be further investigated through randomized controlled trials (RCTs), as it may hold the key to successful treatment for a certain cohort of patients exploring reproductive treatment options following menopause. SAGE Publications 2019-07-04 2019-09 /pmc/articles/PMC6767896/ /pubmed/31271054 http://dx.doi.org/10.1177/0963689719859539 Text en © The Author(s) 2019 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Study
Pantos, Konstantinos
Simopoulou, Mara
Pantou, Agni
Rapani, Anna
Tsioulou, Petroula
Nitsos, Nikolaos
Syrkos, Stephen
Pappas, Athanasios
Koutsilieris, Michael
Sfakianoudis, Konstantinos
A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title_full A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title_fullStr A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title_full_unstemmed A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title_short A Case Series on Natural Conceptions Resulting in Ongoing Pregnancies in Menopausal and Prematurely Menopausal Women Following Platelet-Rich Plasma Treatment
title_sort case series on natural conceptions resulting in ongoing pregnancies in menopausal and prematurely menopausal women following platelet-rich plasma treatment
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767896/
https://www.ncbi.nlm.nih.gov/pubmed/31271054
http://dx.doi.org/10.1177/0963689719859539
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