Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy

In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell...

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Detalles Bibliográficos
Autores principales: Audemard-Verger, Alexandra, Gasnault, Jacques, Faisant, Maxime, Besse, Marie-Catherine, Martin-Silva, Nicolas, Berra, Mado, Fournier, Luc, Boutemy, Jonathan, Maigne, Gwenola, De Boysson, Hubert, Ruet, Alexis, Vabret, Astrid, Chapon, Françoise, Martin-Blondel, Guillaume, Aouba, Achille
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767972/
https://www.ncbi.nlm.nih.gov/pubmed/31660340
http://dx.doi.org/10.1093/ofid/ofz374
Descripción
Sumario:In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1(+) macrophages could be the T-cells partnership in immune exhaustion and virus escape.

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