Cargando…
Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy
In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell...
| Autores principales: | , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2019
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767972/ https://www.ncbi.nlm.nih.gov/pubmed/31660340 http://dx.doi.org/10.1093/ofid/ofz374 |
| _version_ | 1783455029636628480 |
|---|---|
| author | Audemard-Verger, Alexandra Gasnault, Jacques Faisant, Maxime Besse, Marie-Catherine Martin-Silva, Nicolas Berra, Mado Fournier, Luc Boutemy, Jonathan Maigne, Gwenola De Boysson, Hubert Ruet, Alexis Vabret, Astrid Chapon, Françoise Martin-Blondel, Guillaume Aouba, Achille |
| author_facet | Audemard-Verger, Alexandra Gasnault, Jacques Faisant, Maxime Besse, Marie-Catherine Martin-Silva, Nicolas Berra, Mado Fournier, Luc Boutemy, Jonathan Maigne, Gwenola De Boysson, Hubert Ruet, Alexis Vabret, Astrid Chapon, Françoise Martin-Blondel, Guillaume Aouba, Achille |
| author_sort | Audemard-Verger, Alexandra |
| collection | PubMed |
| description | In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1(+) macrophages could be the T-cells partnership in immune exhaustion and virus escape. |
| format | Online Article Text |
| id | pubmed-6767972 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-67679722019-10-03 Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy Audemard-Verger, Alexandra Gasnault, Jacques Faisant, Maxime Besse, Marie-Catherine Martin-Silva, Nicolas Berra, Mado Fournier, Luc Boutemy, Jonathan Maigne, Gwenola De Boysson, Hubert Ruet, Alexis Vabret, Astrid Chapon, Françoise Martin-Blondel, Guillaume Aouba, Achille Open Forum Infect Dis Brief Report In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1(+) macrophages could be the T-cells partnership in immune exhaustion and virus escape. Oxford University Press 2019-09-30 /pmc/articles/PMC6767972/ /pubmed/31660340 http://dx.doi.org/10.1093/ofid/ofz374 Text en © The Author(s) 2019. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Audemard-Verger, Alexandra Gasnault, Jacques Faisant, Maxime Besse, Marie-Catherine Martin-Silva, Nicolas Berra, Mado Fournier, Luc Boutemy, Jonathan Maigne, Gwenola De Boysson, Hubert Ruet, Alexis Vabret, Astrid Chapon, Françoise Martin-Blondel, Guillaume Aouba, Achille Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title | Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title_full | Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title_fullStr | Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title_full_unstemmed | Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title_short | Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy |
| title_sort | sustained response and rationale of programmed cell death-1-targeting for progressive multifocal leukoencephalopathy |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767972/ https://www.ncbi.nlm.nih.gov/pubmed/31660340 http://dx.doi.org/10.1093/ofid/ofz374 |
| work_keys_str_mv | AT audemardvergeralexandra sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT gasnaultjacques sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT faisantmaxime sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT bessemariecatherine sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT martinsilvanicolas sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT berramado sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT fournierluc sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT boutemyjonathan sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT maignegwenola sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT deboyssonhubert sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT ruetalexis sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT vabretastrid sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT chaponfrancoise sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT martinblondelguillaume sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy AT aoubaachille sustainedresponseandrationaleofprogrammedcelldeath1targetingforprogressivemultifocalleukoencephalopathy |