Cargando…

Characterization of epidermal growth factor receptor (EGFR) P848L, an unusual EGFR variant present in lung cancer patients, in a murine Ba/F3 model

Lung cancer patients with mutations in epidermal growth factor receptor (EGFR) benefit from treatments targeting tyrosine kinase inhibitors (TKIs). However, both intrinsic and acquired resistance of tumors to TKIs are common, and EGFR variants have been identified that are resistant to multiple TKIs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sarcar, Bhaswati, Gimbrone, Nicholas T., Wright, Gabriela, Remsing Rix, Lily L., Gordian, Edna R., Rix, Uwe, Chiappori, Alberto A., Reuther, Gary W., Santiago‐Cardona, Pedro G., Muñoz‐Antonia, Teresita, Cress, William Douglas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768113/ https://www.ncbi.nlm.nih.gov/pubmed/31314158 http://dx.doi.org/10.1002/2211-5463.12702

Ejemplares similares

CDK4/6 inhibition synergizes with inhibition of P21-Activated Kinases (PAKs) in lung cancer cell lines
por: Wright, Gabriela M., et al.
Publicado: (2021)

Off-target based drug repurposing opportunities for tivantinib in acute myeloid leukemia
por: Kuenzi, Brent M., et al.
Publicado: (2019)

Dabrafenib inhibits the growth of BRAF‐WT cancers through CDK16 and NEK9 inhibition
por: Phadke, Manali, et al.
Publicado: (2017)

Transforming growth factor β-induced epithelial-to-mesenchymal signature predicts metastasis-free survival in non-small cell lung cancer
por: Gordian, Edna, et al.
Publicado: (2019)

Correction: Transforming growth factor β-induced epithelial-to-mesenchymal signature predicts metastasis-free survival in non-small cell lung cancer
por: Gordian, Edna, et al.
Publicado: (2021)

Translating Hispanic Genomic Factors in Lung Cancer Into Clinical Practice: EGFR Testing for Improved Outcomes
por: Hudson, Janella, et al.
Publicado: (2016)

A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL
por: Rix, Uwe, et al.
Publicado: (2013)

Germ-line exon 21 EGFR mutations, V843I and P848L, in nonsmall cell lung cancer patients
por: Prim, Nathalie, et al.
Publicado: (2014)

Expression of the epidermal growth factor receptor (EGFR) and the phosphorylated EGFR in invasive breast carcinomas
por: Magkou, Christina, et al.
Publicado: (2008)

Phase 1 trial of dasatinib combined with afatinib for epidermal growth factor receptor- (EGFR-) mutated lung cancer with acquired tyrosine kinase inhibitor (TKI) resistance
por: Creelan, Ben C., et al.
Publicado: (2019)

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
por: Li, Jiannong, et al.
Publicado: (2013)

AXL/epidermal growth factor receptor (EGFR) complexes in breast cancer - culprits for resistance to EGFR inhibitors?
por: Heideman, Marinus R, et al.
Publicado: (2013)

Treatment Strategies for Non-Small Cell Lung Cancer with Common EGFR Mutations: A Review of the History of EGFR TKIs Approval and Emerging Data
por: Marin-Acevedo, Julian A., et al.
Publicado: (2023)

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma
por: Makinoshima, Hideki, et al.
Publicado: (2014)

EGFR unusual mutation status in lung adenocarcinomas
por: Alarcão, Ana, et al.
Publicado: (2010)

Epidermal growth factor receptors (EGFR) in human ovarian cancer.
por: Owens, O. J., et al.
Publicado: (1991)

Development of an Epidermal Growth Factor Derivative with EGFR Blocking Activity
por: Panosa, Clara, et al.
Publicado: (2013)

Epidermal Growth Factor Receptor (EGFR) Crosstalks in Liver Cancer
por: Berasain, Carmen, et al.
Publicado: (2011)

Epidermal to Mesenchymal Transition and Failure of EGFR-Targeted Therapy in Glioblastoma
por: Pala, Andrej, et al.
Publicado: (2012)

Nuclear localization of epidermal growth factor receptor (EGFR) in ameloblastomas
por: Pereira, Núbia Braga, et al.
Publicado: (2015)

Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC)
por: Makhov, Petr, et al.
Publicado: (2021)

Epidermal Growth Factor Receptor (EGFR) mutation analysis, gene expression profiling and EGFR protein expression in primary prostate cancer
por: Peraldo-Neia, Caterina, et al.
Publicado: (2011)

Quantification of epidermal growth factor receptor (EGFR) mutation may be a predictor of EGFR‐tyrosine kinase inhibitor treatment response
por: Park, Ha Young, et al.
Publicado: (2016)

Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma
por: Wernicke, A Gabriella, et al.
Publicado: (2010)

Targeting Epidermal Growth Factor Receptor (EGFR) in Pediatric Colorectal Cancer
por: De Pasquale, Maria Debora, et al.
Publicado: (2020)

Association of epidermal growth factor receptor (EGFR) gene polymorphisms with endometriosis
por: Wang, Yu-Mei, et al.
Publicado: (2019)

EGFR mutation frequency in Middle East and African non-small cell lung cancer patients: a systematic review and meta-analysis
por: Benbrahim, Zineb, et al.
Publicado: (2018)

Desmoglein 1–dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesis
por: Getsios, Spiro, et al.
Publicado: (2009)

Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer
por: Weng, Xiaoling, et al.
Publicado: (2015)

Immune Responses to Epidermal Growth Factor Receptor (EGFR) and Their Application for Cancer Treatment
por: Sasada, Tetsuro, et al.
Publicado: (2016)

EGFR signaling coordinates patterning with cell survival during Drosophila epidermal development
por: Crossman, Samuel H., et al.
Publicado: (2018)

Epidermal growth factor receptor (EGFR) downstream signalling pathway in primary colorectal tumours and related metastatic sites: optimising EGFR-targeted treatment options
por: Scartozzi, M, et al.
Publicado: (2007)

Hypoxia-Induced Autophagy Degrades Stromal Lumican into Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma: A Mini-Review
por: Sarcar, Bhaswati, et al.
Publicado: (2019)

The art of botanical illustration
por: Rix, Martyn
Publicado: (1981)

Address
por: Rix, T. G.
Publicado: (1897)

P848: EXPRESSION PROFILE OF BCL-2 FAMILY PROTEINS IN MULTIPLE MYELOMA.
por: Sánchez, Cristina De Ramón, et al.
Publicado: (2023)

Epidermal growth factor receptor (EGFR) mutations in lung cancer: preclinical and clinical data
por: Jorge, S.E.D.C., et al.
Publicado: (2014)

Role of Epidermal Growth Factor Receptor (EGFR) and Its Ligands in Kidney Inflammation and Damage
por: Rayego-Mateos, Sandra, et al.
Publicado: (2018)

Toward structure-based drug design against the epidermal growth factor receptor (EGFR)
por: Haddad, Yazan, et al.
Publicado: (2020)

Prognostic Worth of Epidermal Growth Factor Receptor (EGFR) in Patients with Head and Neck Tumors
por: Barnes, Precious, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ci84npmd280avomm7tnmh3ntur