Cargando…
Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis
PURPOSE: To assess changes in regional ventilation (V), perfusion (Q), and V-Q mismatch in patients with chronic obstructive pulmonary disease (COPD) after pharmacologic treatment using combined xenon-enhanced V and iodine-enhanced Q dual-energy CT (DECT). PATIENTS AND METHODS: Combined V and Q DECT...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768130/ https://www.ncbi.nlm.nih.gov/pubmed/31576116 http://dx.doi.org/10.2147/COPD.S210555 |
_version_ | 1783455059796819968 |
---|---|
author | Hwang, Hye Jeon Lee, Sang Min Seo, Joon Beom Lee, Jae Seung Kim, Namkug Kim, Cherry Oh, Sang Young Lee, Sei Won |
author_facet | Hwang, Hye Jeon Lee, Sang Min Seo, Joon Beom Lee, Jae Seung Kim, Namkug Kim, Cherry Oh, Sang Young Lee, Sei Won |
author_sort | Hwang, Hye Jeon |
collection | PubMed |
description | PURPOSE: To assess changes in regional ventilation (V), perfusion (Q), and V-Q mismatch in patients with chronic obstructive pulmonary disease (COPD) after pharmacologic treatment using combined xenon-enhanced V and iodine-enhanced Q dual-energy CT (DECT). PATIENTS AND METHODS: Combined V and Q DECT were performed at baseline and after three-month pharmacologic treatment in 52 COPD patients. Anatomically co-registered virtual non-contrast images, V, Q, and V/Q(ratio) maps were obtained. V/Q pattern was visually determined to be matched, mismatched, or reversed-mismatched and compared with the regional parenchymal disease patterns of each segment. DECT parameters for V, Q, and V-Q imbalance were quantified. RESULTS: The parenchymal patterns on CT were not changed at follow-up. The segments with matched V/Q pattern were increased (80.2% to 83.6%) as the segments with reversed-mismatched V/Q pattern were decreased with improving ventilation (17.6% to 13.8%) after treatment. Changes of V/Q patterns were mostly observed in segments with bronchial wall thickening. Compared with patients without bronchial wall thickening, the quantified DECT parameters of V-Q imbalance were significantly improved in patients with bronchial wall thickening (p < 0.05). Changes in forced expiratory volume in one second after treatment were correlated with changes in the quantified DECT parameters (r = 0.327–0.342 or r = −0.406 and −0.303; p < 0.05). CONCLUSION: DECT analysis showed that the V-Q imbalance was improved after the pharmacological treatment in COPD patients, although the parenchymal disease patterns remained unchanged. This improvement of V-Q imbalance may occur mostly in the areas with bronchial wall thickening. |
format | Online Article Text |
id | pubmed-6768130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-67681302019-10-01 Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis Hwang, Hye Jeon Lee, Sang Min Seo, Joon Beom Lee, Jae Seung Kim, Namkug Kim, Cherry Oh, Sang Young Lee, Sei Won Int J Chron Obstruct Pulmon Dis Original Research PURPOSE: To assess changes in regional ventilation (V), perfusion (Q), and V-Q mismatch in patients with chronic obstructive pulmonary disease (COPD) after pharmacologic treatment using combined xenon-enhanced V and iodine-enhanced Q dual-energy CT (DECT). PATIENTS AND METHODS: Combined V and Q DECT were performed at baseline and after three-month pharmacologic treatment in 52 COPD patients. Anatomically co-registered virtual non-contrast images, V, Q, and V/Q(ratio) maps were obtained. V/Q pattern was visually determined to be matched, mismatched, or reversed-mismatched and compared with the regional parenchymal disease patterns of each segment. DECT parameters for V, Q, and V-Q imbalance were quantified. RESULTS: The parenchymal patterns on CT were not changed at follow-up. The segments with matched V/Q pattern were increased (80.2% to 83.6%) as the segments with reversed-mismatched V/Q pattern were decreased with improving ventilation (17.6% to 13.8%) after treatment. Changes of V/Q patterns were mostly observed in segments with bronchial wall thickening. Compared with patients without bronchial wall thickening, the quantified DECT parameters of V-Q imbalance were significantly improved in patients with bronchial wall thickening (p < 0.05). Changes in forced expiratory volume in one second after treatment were correlated with changes in the quantified DECT parameters (r = 0.327–0.342 or r = −0.406 and −0.303; p < 0.05). CONCLUSION: DECT analysis showed that the V-Q imbalance was improved after the pharmacological treatment in COPD patients, although the parenchymal disease patterns remained unchanged. This improvement of V-Q imbalance may occur mostly in the areas with bronchial wall thickening. Dove 2019-09-25 /pmc/articles/PMC6768130/ /pubmed/31576116 http://dx.doi.org/10.2147/COPD.S210555 Text en © 2019 Hwang et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Hwang, Hye Jeon Lee, Sang Min Seo, Joon Beom Lee, Jae Seung Kim, Namkug Kim, Cherry Oh, Sang Young Lee, Sei Won Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title_full | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title_fullStr | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title_full_unstemmed | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title_short | Assessment Of Changes In Regional Xenon-Ventilation, Perfusion, And Ventilation-Perfusion Mismatch Using Dual-Energy Computed Tomography After Pharmacological Treatment In Patients With Chronic Obstructive Pulmonary Disease: Visual And Quantitative Analysis |
title_sort | assessment of changes in regional xenon-ventilation, perfusion, and ventilation-perfusion mismatch using dual-energy computed tomography after pharmacological treatment in patients with chronic obstructive pulmonary disease: visual and quantitative analysis |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768130/ https://www.ncbi.nlm.nih.gov/pubmed/31576116 http://dx.doi.org/10.2147/COPD.S210555 |
work_keys_str_mv | AT hwanghyejeon assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT leesangmin assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT seojoonbeom assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT leejaeseung assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT kimnamkug assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT kimcherry assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT ohsangyoung assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis AT leeseiwon assessmentofchangesinregionalxenonventilationperfusionandventilationperfusionmismatchusingdualenergycomputedtomographyafterpharmacologicaltreatmentinpatientswithchronicobstructivepulmonarydiseasevisualandquantitativeanalysis |