Palladium-catalyzed borylation of aryl (pseudo)halides and its applications in biaryl synthesis

A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied t...

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Detalles Bibliográficos
Autores principales: Ji, Hong, Cai, Jianghong, Gan, Nana, Wang, Zhaohua, Wu, Liyang, Li, Guorong, Yi, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768141/
https://www.ncbi.nlm.nih.gov/pubmed/30564982
http://dx.doi.org/10.1186/s13065-018-0510-6
Descripción
Sumario:A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki–Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biaryl analogs is accomplished at room temperature using the strategy, which enhances the practical usefulness of this method. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13065-018-0510-6) contains supplementary material, which is available to authorized users.

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