Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Vandetanib (Caprelsa tablets, VNT) is an orally inhibitor of vascular endothelial growth factor receptor 2. The current research reports the characterization and identification of in vitro, in vivo and reactive intermediates of VNT. In vitro metabolites of VNT were performed by incubation with rat l...

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Detalles Bibliográficos
Autores principales: Attwa, Mohamed W., Kadi, Adnan A., Darwish, Hany W., Amer, Sawsan M., Al-shakliah, Nasser S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768145/
https://www.ncbi.nlm.nih.gov/pubmed/30251155
http://dx.doi.org/10.1186/s13065-018-0467-5

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