Cargando…

A MetAP2 inhibitor blocks adipogenesis, yet improves glucose uptake in cells

Adipose tissue expansion involves angiogenesis to remodel its capillary network. The enzymemethionine aminopeptidase 2(MetAP2) promotes angiogenesis.MetAP2 inhibitors suppress angiogenesis and have potential anti-obesity effect. However, impairment in adipose tissue expansion is also linked with imp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Siddik, Md Abu Bakkar, Das, Bhaskar C., Weiss, Louis, Dhurandhar, Nikhil V., Hegde, Vijay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768232/ https://www.ncbi.nlm.nih.gov/pubmed/31264515 http://dx.doi.org/10.1080/21623945.2019.1636627

Ejemplares similares

MetAP1 and MetAP2 drive cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state
por: Frottin, Frédéric, et al.
Publicado: (2016)

Comprehensive comparison of MetAP2 tissue and cellular expression pattern in lean and obese rodents
por: Han, Jing, et al.
Publicado: (2018)

Antidiabetic E4orf1 protein prevents hepatic steatosis and reduces markers of aging-related cellular damage in high fat fed older mice
por: Mostofinejad, Zahra, et al.
Publicado: (2021)

Design, Synthesis and Mechanistic Studies of Novel Isatin-Pyrazole Hydrazone Conjugates as Selective and Potent Bacterial MetAP Inhibitors
por: Irfan, Iram, et al.
Publicado: (2022)

Neutral metalloaminopeptidases APN and MetAP2 as newly discovered anticancer molecular targets of actinomycin D and its simple analogs
por: Węglarz-Tomczak, Ewelina, et al.
Publicado: (2018)

MetAP-like Ebp1 occupies the human ribosomal tunnel exit and recruits flexible rRNA expansion segments
por: Wild, Klemens, et al.
Publicado: (2020)

Longevity-Extending MetAP2 Inhibitors Induce Caloric Restriction Through P53-Dependent Induction of GDF-15
por: MacArthur, Michael, et al.
Publicado: (2020)

Fumagillin regulates stemness and malignancies in cancer stem-like cells derived from liver cancer via targeting to MetAP-2
por: Zhang, Ke, et al.
Publicado: (2023)

Single and multiple dose evaluation of a novel MetAP2 inhibitor: Results of a randomized, double‐blind, placebo‐controlled clinical trial
por: Malloy, Jaret, et al.
Publicado: (2018)

Computational validation of 3-ammonio-3-(4-oxido- 1H-imidazol-1-ium-5-yl) propane-1, 1-bis (olate) as a potent anti-tubercular drug against mt-MetAP
por: Chowdhury, Abhishek, et al.
Publicado: (2012)

E4orf1 Enhances Glucose Uptake Independent of Proximal Insulin Signaling
por: Na, Ha-Na, et al.
Publicado: (2016)

Potentially modifiable factors to reduce severity of COVID-19 in type 2 diabetes
por: Dhurandhar, Nikhil V., et al.
Publicado: (2020)

E4orf1: A protein for enhancing glucose uptake despite impaired proximal insulin signaling
por: Shastri, Anuradha A., et al.
Publicado: (2018)

metaP-Server: A Web-Based Metabolomics Data Analysis Tool
por: Kastenmüller, Gabi, et al.
Publicado: (2011)

METAP1 Mutation Is a Novel Candidate for Autosomal Recessive Intellectual Disability
por: Caglayan, Ahmet Okay, et al.
Publicado: (2020)

E4orf1 protein reduces the need for endogenous insulin
por: Peddibhotla, Swetha, et al.
Publicado: (2019)

E4orf1, an Adeno-viral protein, attenuates renal lipid accumulation in high fat fed mice: A novel approach to reduce a key risk factor for chronic kidney disease
por: Afruza, Rownock, et al.
Publicado: (2020)

Recent Progress on Branched-Chain Amino Acids in Obesity, Diabetes, and Beyond
por: Siddik, Md Abu Bakkar, et al.
Publicado: (2019)

Reducing endogenous insulin is linked with protection against hepatic steatosis in mice
por: Akheruzzaman, Md, et al.
Publicado: (2020)

The role of Fintech in circular economy practices to improve sustainability performance: a two-staged SEM-ANN approach
por: Siddik, Abu Bakkar, et al.
Publicado: (2023)

E4orf1 Prevents Progression of Fatty Liver Disease in Mice on High Fat Diet
por: Afruza, Rownock, et al.
Publicado: (2022)

The triumvirate: why hypertension, obesity, and diabetes are risk factors for adverse effects in patients with COVID-19
por: Shah, Harsh, et al.
Publicado: (2021)

CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2
por: He, Wei-Peng, et al.
Publicado: (2020)

Doxycycline-Regulated 3T3-L1 Preadipocyte Cell Line with Inducible, Stable Expression of Adenoviral E4orf1 Gene: A Cell Model to Study Insulin-Independent Glucose Disposal
por: Krishnapuram, Rashmi, et al.
Publicado: (2013)

The effect of Fintech adoption on green finance and environmental performance of banking institutions during the COVID-19 pandemic: the role of green innovation
por: Guang-Wen, Zheng, et al.
Publicado: (2022)

E4orf1 improves adipose tissue-specific metabolic risk factors and indicators of cognition function in a mouse model of Alzheimer’s disease
por: Khan, Md Shahjalal Hossain, et al.
Publicado: (2023)

E4orf1: A Novel Ligand That Improves Glucose Disposal in Cell Culture
por: Dhurandhar, Emily J., et al.
Publicado: (2011)

Factors Affecting the Repurchase Intention of Organic Tea among Millennial Consumers: An Empirical Study
por: Tian, Huawei, et al.
Publicado: (2022)

Understanding and Targeting MET Signaling in Solid Tumors - Are We There Yet?
por: Ariyawutyakorn, Witthawat, et al.
Publicado: (2016)

Factors influencing the adoption intention of using mobile financial service during the COVID-19 pandemic: the role of FinTech
por: Yan, Chen, et al.
Publicado: (2021)

E4orf1 Improves Lipid and Glucose Metabolism in Hepatocytes: A Template to Improve Steatosis & Hyperglycemia
por: Dhurandhar, Emily J., et al.
Publicado: (2012)

Organic Foods Purchase Behavior among Generation Y of Bangladesh: The Moderation Effect of Trust and Price Consciousness
por: Zheng, Guang-Wen, et al.
Publicado: (2021)

Interplay of pro- and anti-inflammatory cytokines to determine lipid accretion in adipocytes
por: Wang, Yanning, et al.
Publicado: (2013)

Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
por: Siddik, Md Abu Bakkar, et al.
Publicado: (2022)

Prevalence of depression and its associated factors among undergraduate admission candidates in Bangladesh: A nation-wide cross-sectional study
por: Siddik, Md Abu Bakkar, et al.
Publicado: (2023)

CD24 is required for regulating gene expression, but not glucose uptake, during adipogenesis
por: Smith, Nicole C., et al.
Publicado: (2018)

The Role of Mitochondria-Linked Fatty-Acid Uptake-Driven Adipogenesis in Graves Orbitopathy
por: Zhang, Lei, et al.
Publicado: (2021)

Retrospective Review of MET Gene Mutations
por: Zenali, Maryam, et al.
Publicado: (2015)

E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha
por: Pal, Pooja, et al.
Publicado: (2013)

Neural Underpinnings of Obesity: The Role of Oxidative Stress and Inflammation in the Brain
por: Mullins, Caitlyn A., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ipksel7e2e9ra5vapmiktljhhp