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Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression

Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells ex...

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Autores principales: Wu, Qi, Sun, Si, Li, Zhiyu, Yang, Qian, Li, Bei, Zhu, Shan, Wang, Lijun, Wu, Juan, Yuan, Jingping, Wang, Changhua, Li, Juanjuan, Sun, Shengrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768245/
https://www.ncbi.nlm.nih.gov/pubmed/30474469
http://dx.doi.org/10.1080/21623945.2018.1551688
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author Wu, Qi
Sun, Si
Li, Zhiyu
Yang, Qian
Li, Bei
Zhu, Shan
Wang, Lijun
Wu, Juan
Yuan, Jingping
Wang, Changhua
Li, Juanjuan
Sun, Shengrong
author_facet Wu, Qi
Sun, Si
Li, Zhiyu
Yang, Qian
Li, Bei
Zhu, Shan
Wang, Lijun
Wu, Juan
Yuan, Jingping
Wang, Changhua
Li, Juanjuan
Sun, Shengrong
author_sort Wu, Qi
collection PubMed
description Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells exhibit an aggressive phenotype via inducing epithelial-mesenchymal transition while breast cancer-derived exosomes increased catabolism and release the metabolites in adipocytes and muscle cells. In adipocytes, cancer cell-secreted miR-155 promotes beige/brown differentiation and remodel metabolism in resident adipocytes by downregulating the PPARγ expression, but does not significantly affect biological conversion in C2C12. Likewise, propranolol ameliorates tumour exosomes-associated cachectic wasting through upregulating the PPARγ expression. In summary, we have demonstrated that the transfer of miR-155 from exosomes acts as an oncogenic signal reprograming systemic energy metabolism and leading to cancer-associated cachexia in breast cancer.
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spelling pubmed-67682452019-10-09 Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression Wu, Qi Sun, Si Li, Zhiyu Yang, Qian Li, Bei Zhu, Shan Wang, Lijun Wu, Juan Yuan, Jingping Wang, Changhua Li, Juanjuan Sun, Shengrong Adipocyte Research Paper Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells exhibit an aggressive phenotype via inducing epithelial-mesenchymal transition while breast cancer-derived exosomes increased catabolism and release the metabolites in adipocytes and muscle cells. In adipocytes, cancer cell-secreted miR-155 promotes beige/brown differentiation and remodel metabolism in resident adipocytes by downregulating the PPARγ expression, but does not significantly affect biological conversion in C2C12. Likewise, propranolol ameliorates tumour exosomes-associated cachectic wasting through upregulating the PPARγ expression. In summary, we have demonstrated that the transfer of miR-155 from exosomes acts as an oncogenic signal reprograming systemic energy metabolism and leading to cancer-associated cachexia in breast cancer. Taylor & Francis 2018-12-11 /pmc/articles/PMC6768245/ /pubmed/30474469 http://dx.doi.org/10.1080/21623945.2018.1551688 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Wu, Qi
Sun, Si
Li, Zhiyu
Yang, Qian
Li, Bei
Zhu, Shan
Wang, Lijun
Wu, Juan
Yuan, Jingping
Wang, Changhua
Li, Juanjuan
Sun, Shengrong
Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title_full Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title_fullStr Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title_full_unstemmed Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title_short Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
title_sort breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768245/
https://www.ncbi.nlm.nih.gov/pubmed/30474469
http://dx.doi.org/10.1080/21623945.2018.1551688
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