Cargando…
Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression
Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells ex...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768245/ https://www.ncbi.nlm.nih.gov/pubmed/30474469 http://dx.doi.org/10.1080/21623945.2018.1551688 |
_version_ | 1783455070278385664 |
---|---|
author | Wu, Qi Sun, Si Li, Zhiyu Yang, Qian Li, Bei Zhu, Shan Wang, Lijun Wu, Juan Yuan, Jingping Wang, Changhua Li, Juanjuan Sun, Shengrong |
author_facet | Wu, Qi Sun, Si Li, Zhiyu Yang, Qian Li, Bei Zhu, Shan Wang, Lijun Wu, Juan Yuan, Jingping Wang, Changhua Li, Juanjuan Sun, Shengrong |
author_sort | Wu, Qi |
collection | PubMed |
description | Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells exhibit an aggressive phenotype via inducing epithelial-mesenchymal transition while breast cancer-derived exosomes increased catabolism and release the metabolites in adipocytes and muscle cells. In adipocytes, cancer cell-secreted miR-155 promotes beige/brown differentiation and remodel metabolism in resident adipocytes by downregulating the PPARγ expression, but does not significantly affect biological conversion in C2C12. Likewise, propranolol ameliorates tumour exosomes-associated cachectic wasting through upregulating the PPARγ expression. In summary, we have demonstrated that the transfer of miR-155 from exosomes acts as an oncogenic signal reprograming systemic energy metabolism and leading to cancer-associated cachexia in breast cancer. |
format | Online Article Text |
id | pubmed-6768245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-67682452019-10-09 Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression Wu, Qi Sun, Si Li, Zhiyu Yang, Qian Li, Bei Zhu, Shan Wang, Lijun Wu, Juan Yuan, Jingping Wang, Changhua Li, Juanjuan Sun, Shengrong Adipocyte Research Paper Cancer-secreted exosomes are emerging mediators of cancer-associated cachexia. Here, we show that miR-155 secreted by breast cancer cells is a potent role on the catabolism of adipocytes and muscle cells through targeting the PPARγ. After cocultivated with mature adipocytes or C2C12, tumour cells exhibit an aggressive phenotype via inducing epithelial-mesenchymal transition while breast cancer-derived exosomes increased catabolism and release the metabolites in adipocytes and muscle cells. In adipocytes, cancer cell-secreted miR-155 promotes beige/brown differentiation and remodel metabolism in resident adipocytes by downregulating the PPARγ expression, but does not significantly affect biological conversion in C2C12. Likewise, propranolol ameliorates tumour exosomes-associated cachectic wasting through upregulating the PPARγ expression. In summary, we have demonstrated that the transfer of miR-155 from exosomes acts as an oncogenic signal reprograming systemic energy metabolism and leading to cancer-associated cachexia in breast cancer. Taylor & Francis 2018-12-11 /pmc/articles/PMC6768245/ /pubmed/30474469 http://dx.doi.org/10.1080/21623945.2018.1551688 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Paper Wu, Qi Sun, Si Li, Zhiyu Yang, Qian Li, Bei Zhu, Shan Wang, Lijun Wu, Juan Yuan, Jingping Wang, Changhua Li, Juanjuan Sun, Shengrong Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title | Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title_full | Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title_fullStr | Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title_full_unstemmed | Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title_short | Breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
title_sort | breast cancer-released exosomes trigger cancer-associated cachexia to promote tumor progression |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768245/ https://www.ncbi.nlm.nih.gov/pubmed/30474469 http://dx.doi.org/10.1080/21623945.2018.1551688 |
work_keys_str_mv | AT wuqi breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT sunsi breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT lizhiyu breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT yangqian breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT libei breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT zhushan breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT wanglijun breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT wujuan breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT yuanjingping breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT wangchanghua breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT lijuanjuan breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression AT sunshengrong breastcancerreleasedexosomestriggercancerassociatedcachexiatopromotetumorprogression |