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Maintaining mitochondria in beige adipose tissue

Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. The beige adipocyte is an inducib...

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Detalles Bibliográficos
Autor principal: Lu, Xiaodan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768281/
https://www.ncbi.nlm.nih.gov/pubmed/30686106
http://dx.doi.org/10.1080/21623945.2019.1574194
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author Lu, Xiaodan
author_facet Lu, Xiaodan
author_sort Lu, Xiaodan
collection PubMed
description Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. The beige adipocyte is an inducible form of adipocyte that emerges in response to cold exposure and some other external stimuli. To perform its thermogenic function, its level of mitochondria increases dramatically. If the stimuli are removed the mitochondrial levels return to base line. Following the withdrawal of external stimuli, beige adipocytes directly acquire a white fat-like phenotype through mitophagy-mediated mitochondrial degradation. The beige cell is therefore a dynamic model for studying the mechanism of mitochondrial biogenesis and degradation.
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spelling pubmed-67682812019-10-09 Maintaining mitochondria in beige adipose tissue Lu, Xiaodan Adipocyte Commissioned Individual cell types vary enormously in the amount of different organelles they contain. One such organelle is the mitochondrion. Understanding how mitochondrial levels are controlled is essential since so many disease states seem to involve mitochondrial function. The beige adipocyte is an inducible form of adipocyte that emerges in response to cold exposure and some other external stimuli. To perform its thermogenic function, its level of mitochondria increases dramatically. If the stimuli are removed the mitochondrial levels return to base line. Following the withdrawal of external stimuli, beige adipocytes directly acquire a white fat-like phenotype through mitophagy-mediated mitochondrial degradation. The beige cell is therefore a dynamic model for studying the mechanism of mitochondrial biogenesis and degradation. Taylor & Francis 2019-02-20 /pmc/articles/PMC6768281/ /pubmed/30686106 http://dx.doi.org/10.1080/21623945.2019.1574194 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commissioned
Lu, Xiaodan
Maintaining mitochondria in beige adipose tissue
title Maintaining mitochondria in beige adipose tissue
title_full Maintaining mitochondria in beige adipose tissue
title_fullStr Maintaining mitochondria in beige adipose tissue
title_full_unstemmed Maintaining mitochondria in beige adipose tissue
title_short Maintaining mitochondria in beige adipose tissue
title_sort maintaining mitochondria in beige adipose tissue
topic Commissioned
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768281/
https://www.ncbi.nlm.nih.gov/pubmed/30686106
http://dx.doi.org/10.1080/21623945.2019.1574194
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