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Drivers of HIV-1 transmission: The Portuguese case

BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots a...

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Autores principales: Pineda-Peña, Andrea-Clemencia, Pingarilho, Marta, Li, Guangdi, Vrancken, Bram, Libin, Pieter, Gomes, Perpétua, Camacho, Ricardo Jorge, Theys, Kristof, Barroso Abecasis, Ana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768452/
https://www.ncbi.nlm.nih.gov/pubmed/31568476
http://dx.doi.org/10.1371/journal.pone.0218226
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author Pineda-Peña, Andrea-Clemencia
Pingarilho, Marta
Li, Guangdi
Vrancken, Bram
Libin, Pieter
Gomes, Perpétua
Camacho, Ricardo Jorge
Theys, Kristof
Barroso Abecasis, Ana
author_facet Pineda-Peña, Andrea-Clemencia
Pingarilho, Marta
Li, Guangdi
Vrancken, Bram
Libin, Pieter
Gomes, Perpétua
Camacho, Ricardo Jorge
Theys, Kristof
Barroso Abecasis, Ana
author_sort Pineda-Peña, Andrea-Clemencia
collection PubMed
description BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were collected from 3599 HIV-1 naive patients between 2001 and 2014. Sequences obtained from drug resistance testing were used for subtyping, TDR determination and transmission clusters (TC) analyses. RESULTS: In Portugal, transmission of subtype B was significantly associated with young males, while transmission of subtype G was associated with older heterosexuals. In Portuguese originated people, there was a decreasing trend both for prevalence of subtype G and for number of TCs in this subtype. The active TCs that were identified (i.e. clusters originated after 2008) were associated with subtype B-infected males residing in Lisbon. TDR was significantly different when comparing subtypes B (10.8% [9.5–12.2]) and G (7.6% [6.4–9.0]) (p = 0.001). DISCUSSION: TC analyses shows that, in Portugal, the subtype B epidemic is active and fueled by young male patients residing in Lisbon, while transmission of subtype G is decreasing. Despite similar treatment rates for both subtypes in Portugal, TDR is significantly different between subtypes.
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spelling pubmed-67684522019-10-12 Drivers of HIV-1 transmission: The Portuguese case Pineda-Peña, Andrea-Clemencia Pingarilho, Marta Li, Guangdi Vrancken, Bram Libin, Pieter Gomes, Perpétua Camacho, Ricardo Jorge Theys, Kristof Barroso Abecasis, Ana PLoS One Research Article BACKGROUND: Portugal has one of the most severe HIV-1 epidemics in Western Europe. Two subtypes circulate in parallel since the beginning of the epidemic. Comparing their transmission patterns and its association with transmitted drug resistance (TDR) is important to pinpoint transmission hotspots and to develop evidence-based treatment guidelines. METHODS: Demographic, clinical and genomic data were collected from 3599 HIV-1 naive patients between 2001 and 2014. Sequences obtained from drug resistance testing were used for subtyping, TDR determination and transmission clusters (TC) analyses. RESULTS: In Portugal, transmission of subtype B was significantly associated with young males, while transmission of subtype G was associated with older heterosexuals. In Portuguese originated people, there was a decreasing trend both for prevalence of subtype G and for number of TCs in this subtype. The active TCs that were identified (i.e. clusters originated after 2008) were associated with subtype B-infected males residing in Lisbon. TDR was significantly different when comparing subtypes B (10.8% [9.5–12.2]) and G (7.6% [6.4–9.0]) (p = 0.001). DISCUSSION: TC analyses shows that, in Portugal, the subtype B epidemic is active and fueled by young male patients residing in Lisbon, while transmission of subtype G is decreasing. Despite similar treatment rates for both subtypes in Portugal, TDR is significantly different between subtypes. Public Library of Science 2019-09-30 /pmc/articles/PMC6768452/ /pubmed/31568476 http://dx.doi.org/10.1371/journal.pone.0218226 Text en © 2019 Pineda-Peña et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Pineda-Peña, Andrea-Clemencia
Pingarilho, Marta
Li, Guangdi
Vrancken, Bram
Libin, Pieter
Gomes, Perpétua
Camacho, Ricardo Jorge
Theys, Kristof
Barroso Abecasis, Ana
Drivers of HIV-1 transmission: The Portuguese case
title Drivers of HIV-1 transmission: The Portuguese case
title_full Drivers of HIV-1 transmission: The Portuguese case
title_fullStr Drivers of HIV-1 transmission: The Portuguese case
title_full_unstemmed Drivers of HIV-1 transmission: The Portuguese case
title_short Drivers of HIV-1 transmission: The Portuguese case
title_sort drivers of hiv-1 transmission: the portuguese case
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768452/
https://www.ncbi.nlm.nih.gov/pubmed/31568476
http://dx.doi.org/10.1371/journal.pone.0218226
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