Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes

BACKGROUND: Myriad challenges to the proper folding and structural maturation of secretory pathway client proteins in the endoplasmic reticulum (ER) — a condition referred to as “ER stress” — activate intracellular signaling pathways termed the unfolded protein response (UPR). SCOPE OF REVIEW: Throu...

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Detalles Bibliográficos
Autores principales: Ghosh, Rajarshi, Colon-Negron, Kevin, Papa, Feroz R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768499/
https://www.ncbi.nlm.nih.gov/pubmed/31500832
http://dx.doi.org/10.1016/j.molmet.2019.06.012

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