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Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights

BACKGROUND: Obesity and type 2 diabetes (T2D) are major public health issues worldwide, and put a significant burden on the healthcare system. Genetic variants, along with traditional risk factors such as diet and physical activity, could account for up to approximately a quarter of disease risk. Ep...

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Detalles Bibliográficos
Autores principales: Loh, Marie, Zhou, Li, Ng, Hong Kiat, Chambers, John Campbell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768506/
https://www.ncbi.nlm.nih.gov/pubmed/31500829
http://dx.doi.org/10.1016/j.molmet.2019.06.011
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author Loh, Marie
Zhou, Li
Ng, Hong Kiat
Chambers, John Campbell
author_facet Loh, Marie
Zhou, Li
Ng, Hong Kiat
Chambers, John Campbell
author_sort Loh, Marie
collection PubMed
description BACKGROUND: Obesity and type 2 diabetes (T2D) are major public health issues worldwide, and put a significant burden on the healthcare system. Genetic variants, along with traditional risk factors such as diet and physical activity, could account for up to approximately a quarter of disease risk. Epigenetic factors have demonstrated potential in accounting for additional phenotypic variation, along with providing insights into the causal relationship linking genetic variants to phenotypes. SCOPE OF REVIEW: In this review article, we discuss the epidemiological and functional insights into epigenetic disturbances in obesity and diabetes, along with future research directions and approaches, with a focus on DNA methylation. MAJOR CONCLUSIONS: Epigenetic mechanisms have been shown to contribute to obesity and T2D disease development, as well as potential differences in disease risks between ethnic populations. Technology to investigate epigenetic profiles in diseased individuals and tissues has advanced significantly in the last years, and suggests potential in application of epigenetic factors in clinical monitoring and as therapeutic options.
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spelling pubmed-67685062019-10-07 Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights Loh, Marie Zhou, Li Ng, Hong Kiat Chambers, John Campbell Mol Metab Review BACKGROUND: Obesity and type 2 diabetes (T2D) are major public health issues worldwide, and put a significant burden on the healthcare system. Genetic variants, along with traditional risk factors such as diet and physical activity, could account for up to approximately a quarter of disease risk. Epigenetic factors have demonstrated potential in accounting for additional phenotypic variation, along with providing insights into the causal relationship linking genetic variants to phenotypes. SCOPE OF REVIEW: In this review article, we discuss the epidemiological and functional insights into epigenetic disturbances in obesity and diabetes, along with future research directions and approaches, with a focus on DNA methylation. MAJOR CONCLUSIONS: Epigenetic mechanisms have been shown to contribute to obesity and T2D disease development, as well as potential differences in disease risks between ethnic populations. Technology to investigate epigenetic profiles in diseased individuals and tissues has advanced significantly in the last years, and suggests potential in application of epigenetic factors in clinical monitoring and as therapeutic options. Elsevier 2019-09-06 /pmc/articles/PMC6768506/ /pubmed/31500829 http://dx.doi.org/10.1016/j.molmet.2019.06.011 Text en © 2019 Published by Elsevier GmbH. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Loh, Marie
Zhou, Li
Ng, Hong Kiat
Chambers, John Campbell
Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title_full Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title_fullStr Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title_full_unstemmed Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title_short Epigenetic disturbances in obesity and diabetes: Epidemiological and functional insights
title_sort epigenetic disturbances in obesity and diabetes: epidemiological and functional insights
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768506/
https://www.ncbi.nlm.nih.gov/pubmed/31500829
http://dx.doi.org/10.1016/j.molmet.2019.06.011
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