Targeted genomic CRISPR-Cas9 screen identifies MAP4K4 as essential for glioblastoma invasion

Among high-grade brain tumors, glioblastoma is particularly difficult to treat, in part due to its highly infiltrative nature which contributes to the malignant phenotype and high mortality in patients. In order to better understand the signaling pathways underlying glioblastoma invasion, we perform...

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Detalles Bibliográficos
Autores principales: Prolo, Laura M., Li, Amy, Owen, Scott F., Parker, Jonathon J., Foshay, Kara, Nitta, Ryan T., Morgens, David W., Bolin, Sara, Wilson, Christy M., Vega L, Johana C. M., Luo, Emily J., Nwagbo, Gigi, Waziri, Allen, Li, Gordon, Reimer, Richard J., Bassik, Michael C., Grant, Gerald A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768851/
https://www.ncbi.nlm.nih.gov/pubmed/31570734
http://dx.doi.org/10.1038/s41598-019-50160-w

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