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Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

To endure over the organismal lifespan, neurons utilize multiple strategies to achieve protein homeostasis (proteostasis). Some homeostatic mechanisms act in a subcellular compartment-specific manner, but others exhibit trans-compartmental mechanisms of proteostasis. To identify pathways protecting...

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Detalles Bibliográficos
Autores principales:	Waldherr, Sarah M., Strovas, Timothy J., Vadset, Taylor A., Liachko, Nicole F., Kraemer, Brian C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768869/ https://www.ncbi.nlm.nih.gov/pubmed/31570707 http://dx.doi.org/10.1038/s41467-019-12070-3

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