Cargando…

Development of a Bispecific Antibody Targeting CD30 and CD137 on Hodgkin and Reed-Sternberg Cells

Hodgkin Lymphoma (HL) is a malignancy that frequently affects young adults. Although, there are effective treatments not every patient responds, necessitating the development of novel therapeutic approaches, especially for relapsed and refractory cases. The two TNF receptor family members CD30 and C...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rajendran, Sakthi, Li, Yating, Ngoh, Evelyn, Wong, Hiu Yi, Cheng, Man Si, Wang, Cheng-I, Schwarz, Herbert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6768943/ https://www.ncbi.nlm.nih.gov/pubmed/31616638 http://dx.doi.org/10.3389/fonc.2019.00945

Ejemplares similares

Ectopic CD137 expression facilitates the escape of Hodgkin and Reed-Sternberg cells from immunosurveillance
por: Pang, Wan Lu, et al.
Publicado: (2013)

CD20 Over-Expression in Hodgkin-Reed-Sternberg Cells of Classical Hodgkin Lymphoma: the Neglected Quest
por: Benharroch, Daniel, et al.
Publicado: (2015)

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma
por: Parente, Paola, et al.
Publicado: (2020)

CD30 induces Reed‐Sternberg cell‐like morphology and chromosomal instability in classic Hodgkin lymphoma cell lines
por: Watanabe, Mariko, et al.
Publicado: (2023)

New molecular targets in Hodgkin and Reed-Sternberg cells
por: Sadaf, Hummaira, et al.
Publicado: (2023)

Glycoproteomic characterization of carriers of the CD15/Lewis(x )epitope on Hodgkin's Reed-Sternberg cells
por: Powlesland, Alex S, et al.
Publicado: (2011)

Primary Refractory and Relapsed Classical Hodgkin Lymphoma - Significance of Differential CD15 Expression in Hodgkin-Reed-Sternberg Cells
por: Benharroch, Daniel, et al.
Publicado: (2012)

P035: CRISPR/Cas9-mediated knockout reveals an important role of CD30 in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma
por: Kilian, Annika L., et al.
Publicado: (2022)

p53 expression in Reed-Sternberg cells of Hodgkin's disease.
por: Gupta, R. K., et al.
Publicado: (1992)

Loss of heterozygosity in the Hodgkin-Reed Sternberg cell line L1236
por: Staratschek-Jox, A, et al.
Publicado: (2001)

Characteristics of Sternberg-Reed, and related cells in Hodgkin's disease: an immunohistological study.
por: Dorreen, M. S., et al.
Publicado: (1984)

Interleukin 13 Is Secreted by and Stimulates the Growth of Hodgkin and Reed-Sternberg Cells
por: Kapp, Ursula, et al.
Publicado: (1999)

Reed-Sternberg cells in Hodgkin's lymphoma present features of cellular senescence
por: Gopas, J, et al.
Publicado: (2016)

IMMUNOHISTOCHEMICAL DEMONSTRATION OF IgG IN REED-STERNBERG AND OTHER CELLS IN HODGKIN'S DISEASE
por: Garvin, A. J., et al.
Publicado: (1974)

Reed Sternberg-Like Cells in Non-Hodgkin Lymphoma: A Diagnostic Challenge
por: Yadav, Geeta, et al.
Publicado: (2022)

JAK/STAT blockade reverses the malignant phenotype of Hodgkin and Reed-Sternberg cells
por: Fernández, Sara, et al.
Publicado: (2022)

Reed-Sternberg and Hodgkin cells in bone marrow aspirate from a classical Hodgkin lymphoma patient
por: Oliveira, Leonardo Rodrigues, et al.
Publicado: (2022)

P031: CD4+ T cells in close proximity to Hodgkin-Reed Sternberg cells are antigen experienced, polyclonal and display an exhausted phenotype
por: Veldman, Johanna, et al.
Publicado: (2022)

Reed-Sternberg-like cells in follicular lymphoma
por: Son, Eun-mi, et al.
Publicado: (2014)

c-FLIP Mediates Resistance of Hodgkin/Reed-Sternberg Cells to Death Receptor–induced Apoptosis
por: Mathas, Stephan, et al.
Publicado: (2004)

100-year-old Haematologica images: Hodgkin and Reed-Sternberg cells in needle aspiration of the spleen
por: Balduini, Carlo L.
Publicado: (2020)

Tackling the dysregulated immune-checkpoints in classical Hodgkin lymphoma: bidirectional regulations between the microenvironment and Hodgkin/Reed-Sternberg cells
por: Cellini, Alessandro, et al.
Publicado: (2023)

Distinct 3D Structural Patterns of Lamin A/C Expression in Hodgkin and Reed-Sternberg Cells
por: Contu, Fabio, et al.
Publicado: (2018)

Basal autophagy is pivotal for Hodgkin and Reed-Sternberg cells' survival and growth revealing a new strategy for Hodgkin lymphoma treatment
por: Birkenmeier, Katrin, et al.
Publicado: (2016)

Deep Sequencing of Immunoglobulin Genes Identifies a Very Low Percentage of Monoclonal B Cells in Primary Cutaneous Marginal Zone Lymphomas with CD30-Positive Hodgkin/Reed–Sternberg-like Cells
por: Di Napoli, Arianna, et al.
Publicado: (2022)

Differences in Nuclear DNA Organization Between Lymphocytes, Hodgkin and Reed–Sternberg Cells Revealed by Structured Illumination Microscopy
por: Righolt, Christiaan H, et al.
Publicado: (2014)

Genomic analyses of microdissected Hodgkin and Reed-Sternberg cells: mutations in epigenetic regulators and p53 are frequent in refractory classic Hodgkin lymphoma
por: Mata, Elena, et al.
Publicado: (2019)

The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma
por: Zijtregtop, Eline A. M., et al.
Publicado: (2022)

Identification of CD137-Expressing B Cells in Multiple Sclerosis Which Secrete IL-6 Upon Engagement by CD137 Ligand
por: Wong, Hiu Yi, et al.
Publicado: (2020)

The Reed-Sternberg cell/lymphocyte rosette. I. Properties of rosettes formed between Hodgkin's cell lines and allogeneic lymphocytes.
por: Flavell, D. J., et al.
Publicado: (1989)

Primary Cutaneous Follicle Centre Lymphoma with Hodgkin and Reed-Sternberg Like Cells: A Case Report and Review of the Literature
por: Aldarweesh, Fatima A., et al.
Publicado: (2017)

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma
por: Campos, Antonio Hugo, et al.
Publicado: (2013)

P038: HLA expression patterns of Hodgkin-Reed-Sternberg cells shape a spatially arranged tumor microenvironment in classical Hodgkin lymphoma
por: Müller-Meinhard, Berit, et al.
Publicado: (2022)

CD137L, a driver of harmful inflammation in the nervous system
por: Wong, Hiu Yi, et al.
Publicado: (2023)

Ectopic CD137 expression by rhabdomyosarcoma provides selection advantages but allows immunotherapeutic targeting
por: Lee, Kang Yi, et al.
Publicado: (2021)

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells
Publicado: (1996)

Targeting Hodgkin and Reed–Sternberg Cells with an Inhibitor of Heat-Shock Protein 90: Molecular Pathways of Response and Potential Mechanisms of Resistance
por: Segges, Priscilla, et al.
Publicado: (2018)

Detection of Epstein‐Barr Virus DNA in Reed‐Sternberg Cells of Hodgkin's Disease Using the Polymerase Chain Reaction and in situ Hybridization
por: Uhara, Hisashi, et al.
Publicado: (1990)

The production of abnormal cells and Reed-Sternberg-like cells from normal lymphocytes.
por: Stuart, A. E.
Publicado: (1983)

The Progress of Investigating the CD137-CD137L Axis as a Potential Target for Systemic Lupus Erythematosus
por: Mak, Anselm, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_hstqiktgq1g91gmaj1cfhgml8d