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Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy
Introduction: Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy. Materials and methods: We performed a systemat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769070/ https://www.ncbi.nlm.nih.gov/pubmed/31612102 http://dx.doi.org/10.3389/fonc.2019.00925 |
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author | Byvaltsev, Vadim A. Bardonova, Liudmila A. Onaka, Naomi R. Polkin, Roman A. Ochkal, Sergey V. Shepelev, Valerij V. Aliyev, Marat A. Potapov, Alexander A. |
author_facet | Byvaltsev, Vadim A. Bardonova, Liudmila A. Onaka, Naomi R. Polkin, Roman A. Ochkal, Sergey V. Shepelev, Valerij V. Aliyev, Marat A. Potapov, Alexander A. |
author_sort | Byvaltsev, Vadim A. |
collection | PubMed |
description | Introduction: Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy. Materials and methods: We performed a systematic search in the MEDLINE, PubMed, Cochrane library, Google Scholar, Embase, Web of Science, and Scopus database using combinations of the term “acridine orange” with the following: “surgical oncology,” “neuropathology,” “microsurgery,” “intraoperative fluorescence,” “confocal microscopy,” “pathology,” “endomicroscopy,” “guidance,” “fluorescence guidance,” “oncology,” “surgery,” “neurooncology,” and “photodynamic therapy.” Peer-reviewed articles published in English were included in this review. We have also scanned references for relevant articles. Results: We have reviewed studies on the various application of AO in microscopy, endomicroscopy, intraoperative fluorescence guidance, photodynamic therapy, sonodynamic therapy, radiodynamic therapy. Conclusion: Although the number of studies on the clinical use of AO is limited, pilot studies have demonstrated the safety and feasibility of its application as an intraoperative fluorescent dye and as a novel photo- and radio-sensitizator. Further clinical studies are necessary to more definitively assess the clinical benefit AO-based fluorescence guidance, therapy for sarcomas, and to establish feasibility of this new approach for the treatment of other tumor types. |
format | Online Article Text |
id | pubmed-6769070 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-67690702019-10-14 Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy Byvaltsev, Vadim A. Bardonova, Liudmila A. Onaka, Naomi R. Polkin, Roman A. Ochkal, Sergey V. Shepelev, Valerij V. Aliyev, Marat A. Potapov, Alexander A. Front Oncol Oncology Introduction: Acridine orange (AO) was first extracted from coal tar in the late nineteenth century and was used as a fluorescent dye. In this paper, we review emergent research about novel applications of AO for fluorescence surgery and cancer therapy. Materials and methods: We performed a systematic search in the MEDLINE, PubMed, Cochrane library, Google Scholar, Embase, Web of Science, and Scopus database using combinations of the term “acridine orange” with the following: “surgical oncology,” “neuropathology,” “microsurgery,” “intraoperative fluorescence,” “confocal microscopy,” “pathology,” “endomicroscopy,” “guidance,” “fluorescence guidance,” “oncology,” “surgery,” “neurooncology,” and “photodynamic therapy.” Peer-reviewed articles published in English were included in this review. We have also scanned references for relevant articles. Results: We have reviewed studies on the various application of AO in microscopy, endomicroscopy, intraoperative fluorescence guidance, photodynamic therapy, sonodynamic therapy, radiodynamic therapy. Conclusion: Although the number of studies on the clinical use of AO is limited, pilot studies have demonstrated the safety and feasibility of its application as an intraoperative fluorescent dye and as a novel photo- and radio-sensitizator. Further clinical studies are necessary to more definitively assess the clinical benefit AO-based fluorescence guidance, therapy for sarcomas, and to establish feasibility of this new approach for the treatment of other tumor types. Frontiers Media S.A. 2019-09-24 /pmc/articles/PMC6769070/ /pubmed/31612102 http://dx.doi.org/10.3389/fonc.2019.00925 Text en Copyright © 2019 Byvaltsev, Bardonova, Onaka, Polkin, Ochkal, Shepelev, Aliyev and Potapov. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Byvaltsev, Vadim A. Bardonova, Liudmila A. Onaka, Naomi R. Polkin, Roman A. Ochkal, Sergey V. Shepelev, Valerij V. Aliyev, Marat A. Potapov, Alexander A. Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title | Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title_full | Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title_fullStr | Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title_full_unstemmed | Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title_short | Acridine Orange: A Review of Novel Applications for Surgical Cancer Imaging and Therapy |
title_sort | acridine orange: a review of novel applications for surgical cancer imaging and therapy |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769070/ https://www.ncbi.nlm.nih.gov/pubmed/31612102 http://dx.doi.org/10.3389/fonc.2019.00925 |
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