Cargando…

The Impairments of α-Synuclein and Mechanistic Target of Rapamycin in Rotenone-Induced SH-SY5Y Cells and Mice Model of Parkinson’s Disease

Parkinson’s disease (PD) is characterized by selective degeneration of dopaminergic (DAergic) neurons in the substantia nigra pars compacta (SNpc). α-synuclein (α-syn) is known to regulate mitochondrial function and both PINK1 and Parkin have been shown to eliminate damaged mitochondria in PD. Mecha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ramalingam, Mahesh, Huh, Yu-Jin, Lee, Yun-Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769080/ https://www.ncbi.nlm.nih.gov/pubmed/31611767 http://dx.doi.org/10.3389/fnins.2019.01028

Ejemplares similares

Hepcidin Decreases Rotenone-Induced α-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Li, Meiqi, et al.
Publicado: (2020)

Ndfip1 Prevents Rotenone-Induced Neurotoxicity and Upregulation of α-Synuclein in SH-SY5Y Cells
por: Liu, Xin, et al.
Publicado: (2021)

Death-associated Protein Kinase 1 Phosphorylates α-Synuclein at Ser129 and Exacerbates Rotenone-induced Toxic Aggregation of α-Synuclein in Dopaminergic SH-SY5Y Cells
por: Shin, Woo Hyun, et al.
Publicado: (2020)

Neural-Induced Human Adipose Tissue-Derived Stem Cells Conditioned Medium Ameliorates Rotenone-Induced Toxicity in SH-SY5Y Cells
por: Ramalingam, Mahesh, et al.
Publicado: (2021)

Baicalein antagonizes rotenone-induced apoptosis in dopaminergic SH-SY5Y cells related to Parkinsonism
por: Song, Ju-Xian, et al.
Publicado: (2012)

Histone Deacetylase 4 Inhibition Reduces Rotenone-Induced Alpha-Synuclein Accumulation via Autophagy in SH-SY5Y Cells
por: Wang, Luxi, et al.
Publicado: (2023)

Growth Differentiation Factor 15 Protects SH-SY5Y Cells From Rotenone-Induced Toxicity by Suppressing Mitochondrial Apoptosis
por: Li, Peizheng, et al.
Publicado: (2022)

Autophagy Signaling by Neural-Induced Human Adipose Tissue-Derived Stem Cell-Conditioned Medium during Rotenone-Induced Toxicity in SH-SY5Y Cells
por: Ramalingam, Mahesh, et al.
Publicado: (2022)

Biophysical Characterization of α-Synuclein and Rotenone Interaction
por: Silva, Blanca A., et al.
Publicado: (2013)

Evaluation of the Combination of Metformin and Rapamycin in an MPP(+)-Treated SH-SY5Y Model of Parkinson's Disease
por: Norradee, Chureerat, et al.
Publicado: (2023)

Rosmarinic Acid Attenuates Rotenone-Induced Neurotoxicity in SH-SY5Y Parkinson’s Disease Cell Model through Abl Inhibition
por: Han, Xiao, et al.
Publicado: (2022)

Rotenone aggravates PD-like pathology in A53T mutant human α-synuclein transgenic mice in an age-dependent manner
por: Chen, An-Di, et al.
Publicado: (2022)

Neuroprotective Effects of Proanthocyanidins, Natural Flavonoids Derived From Plants, on Rotenone-Induced Oxidative Stress and Apoptotic Cell Death in Human Neuroblastoma SH-SY5Y Cells
por: Ma, Jian, et al.
Publicado: (2018)

A Matrigel-based 3D construct of SH-SY5Y cells models the α-synuclein pathologies of Parkinson's disease
por: Li, Zhao-Feng, et al.
Publicado: (2022)

Super-resolution imaging reveals α-synuclein seeded aggregation in SH-SY5Y cells
por: Sang, Jason C., et al.
Publicado: (2021)

Differential Effects of Methyl-4-Phenylpyridinium Ion, Rotenone, and Paraquat on Differentiated SH-SY5Y Cells
por: Martins, João Barbosa, et al.
Publicado: (2013)

Over-expression of survivin could prevent the oxidative stress and toxicity of rotenone in SH-SY5Y cells
por: Rahimmi, Arman, et al.
Publicado: (2022)

LAR Downregulation Protects the Astrocytic U251 and Cocultured SH-SY5Y Cells in a Rotenone-Induced Parkinson’s Disease Cell Model
por: Zheng, Wei, et al.
Publicado: (2023)

Neuroprotective effects of genistein on SH-SY5Y cells overexpressing A53T mutant α-synuclein
por: Wu, Huan-Cheng, et al.
Publicado: (2018)

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson’s disease patients
por: Dieriks, Birger Victor, et al.
Publicado: (2017)

Biomarkers and the Role of α-Synuclein in Parkinson’s Disease
por: Du, Tingting, et al.
Publicado: (2021)

In vitro neuroprotective potential of four medicinal plants against rotenone-induced toxicity in SH-SY5Y neuroblastoma cells
por: Seoposengwe, Keabetswe, et al.
Publicado: (2013)

Neurosupportive Role of Vanillin, a Natural Phenolic Compound, on Rotenone Induced Neurotoxicity in SH-SY5Y Neuroblastoma Cells
por: Dhanalakshmi, Chinnasamy, et al.
Publicado: (2015)

Neuroprotective effect of Demethoxycurcumin, a natural derivative of Curcumin on rotenone induced neurotoxicity in SH-SY 5Y Neuroblastoma cells
por: Ramkumar, Muthu, et al.
Publicado: (2017)

Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational Statistics
por: Simões, Rui F., et al.
Publicado: (2022)

Salidroside Promotes the Pathological α-Synuclein Clearance Through Ubiquitin-Proteasome System in SH-SY5Y Cells
por: Li, Tao, et al.
Publicado: (2018)

Decrease in ITGA7 Levels Is Associated with an Increase in α-Synuclein Levels in an MPTP-Induced Parkinson’s Disease Mouse Model and SH-SY5Y Cells
por: Han, Sangeun, et al.
Publicado: (2021)

Therapeutic Effects of Conditioned Medium of Neural Differentiated Human Bone Marrow-Derived Stem Cells on Rotenone-Induced Alpha-Synuclein Aggregation and Apoptosis
por: Ramalingam, Mahesh, et al.
Publicado: (2021)

Redox-proteomes of human NOS1-transduced versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum-free starvation, and rapamycin treatment
por: Heidler, Juliana, et al.
Publicado: (2018)

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease
por: Bridi, Jessika C., et al.
Publicado: (2018)

Nanoparticles With Affinity for α-Synuclein Sequester α-Synuclein to Form Toxic Aggregates in Neurons With Endolysosomal Impairment
por: Jiang, Peizhou, et al.
Publicado: (2021)

L-Asparaginase Exerts Neuroprotective Effects in an SH-SY5Y-A53T Model of Parkinson’s Disease by Regulating Glutamine Metabolism
por: Zhang, Qingxi, et al.
Publicado: (2020)

Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
por: Ardah, Mustafa T, et al.
Publicado: (2021)

Adenosine A(2A) Receptor Blockade Prevents Rotenone-Induced Motor Impairment in a Rat Model of Parkinsonism
por: Fathalla, Ahmed M., et al.
Publicado: (2016)

Deep proteome of human nNOS/NOS1-positive versus MOCK SH-SY5Y neuroblastoma cells under full nutrition, serum free starvation and rapamycin treatment
por: Heidler, Juliana, et al.
Publicado: (2018)

α-synuclein pathogenesis in hiPSC models of Parkinson’s disease
por: Baena-Montes, Jara M., et al.
Publicado: (2021)

The role of the endolysosomal pathway in α-synuclein pathogenesis in Parkinson’s disease
por: Smith, Jessica K., et al.
Publicado: (2023)

ATP13A2/PARK9 Deficiency Neither Cause Lysosomal Impairment Nor Alter α-Synuclein Metabolism in SH-SY5Y Cells
por: Bae, Eun-Jin, et al.
Publicado: (2014)

Plasma Levels of α-Synuclein, Aβ-40 and T-tau as Biomarkers to Predict Cognitive Impairment in Parkinson’s Disease
por: Chen, Nai-Ching, et al.
Publicado: (2020)

The involvement of Eag1 potassium channels and miR-34a in rotenone-induced death of dopaminergic SH-SY5Y cells
por: Horst, Camila Hillesheim, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_uupglpmv4pbsn9dat01qpr824p