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Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case

Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatric...

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Autores principales: Oliveira, Sofia, Marques, Bernardo, Laranjo, Sérgio, Lopes, Lurdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Scientific Publications, Pavia, Italy 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769358/
https://www.ncbi.nlm.nih.gov/pubmed/31579213
http://dx.doi.org/10.4081/pr.2019.8166
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author Oliveira, Sofia
Marques, Bernardo
Laranjo, Sérgio
Lopes, Lurdes
author_facet Oliveira, Sofia
Marques, Bernardo
Laranjo, Sérgio
Lopes, Lurdes
author_sort Oliveira, Sofia
collection PubMed
description Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating between the main AIT subtypes is quite relevant, since there is specific treatment for both, however, this distinction may be difficult in clinical practice. We describe a rare case of AIT in a pediatric patient, with an uncommon congenital cardiac malformation, that started amiodarone therapy due to paroxysmal supraventricular tachycardia. AIT was reported 26 months after drug onset, with a sudden and explosive emerging. This case highlights the current AIT management challenges on the highdemanding pediatric field pursuing, ultimately, an enhanced patient´s care.
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spelling pubmed-67693582019-10-02 Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case Oliveira, Sofia Marques, Bernardo Laranjo, Sérgio Lopes, Lurdes Pediatr Rep Case Report Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating between the main AIT subtypes is quite relevant, since there is specific treatment for both, however, this distinction may be difficult in clinical practice. We describe a rare case of AIT in a pediatric patient, with an uncommon congenital cardiac malformation, that started amiodarone therapy due to paroxysmal supraventricular tachycardia. AIT was reported 26 months after drug onset, with a sudden and explosive emerging. This case highlights the current AIT management challenges on the highdemanding pediatric field pursuing, ultimately, an enhanced patient´s care. PAGEPress Scientific Publications, Pavia, Italy 2019-09-24 /pmc/articles/PMC6769358/ /pubmed/31579213 http://dx.doi.org/10.4081/pr.2019.8166 Text en ©Copyright: the Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Oliveira, Sofia
Marques, Bernardo
Laranjo, Sérgio
Lopes, Lurdes
Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title_full Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title_fullStr Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title_full_unstemmed Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title_short Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
title_sort amiodarone-induced thyrotoxicosis in a pediatric patient: a rare and demanding clinical case
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769358/
https://www.ncbi.nlm.nih.gov/pubmed/31579213
http://dx.doi.org/10.4081/pr.2019.8166
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