Cargando…
Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case
Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatric...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PAGEPress Scientific Publications, Pavia, Italy
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769358/ https://www.ncbi.nlm.nih.gov/pubmed/31579213 http://dx.doi.org/10.4081/pr.2019.8166 |
_version_ | 1783455225709854720 |
---|---|
author | Oliveira, Sofia Marques, Bernardo Laranjo, Sérgio Lopes, Lurdes |
author_facet | Oliveira, Sofia Marques, Bernardo Laranjo, Sérgio Lopes, Lurdes |
author_sort | Oliveira, Sofia |
collection | PubMed |
description | Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating between the main AIT subtypes is quite relevant, since there is specific treatment for both, however, this distinction may be difficult in clinical practice. We describe a rare case of AIT in a pediatric patient, with an uncommon congenital cardiac malformation, that started amiodarone therapy due to paroxysmal supraventricular tachycardia. AIT was reported 26 months after drug onset, with a sudden and explosive emerging. This case highlights the current AIT management challenges on the highdemanding pediatric field pursuing, ultimately, an enhanced patient´s care. |
format | Online Article Text |
id | pubmed-6769358 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | PAGEPress Scientific Publications, Pavia, Italy |
record_format | MEDLINE/PubMed |
spelling | pubmed-67693582019-10-02 Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case Oliveira, Sofia Marques, Bernardo Laranjo, Sérgio Lopes, Lurdes Pediatr Rep Case Report Thyroid dysfunction is one of the most common adverse effects of amiodarone therapy, ranging from subclinical changes to overt clinical thyrotoxicosis (AIT) and/or hypothyroidism. Due to its heterogeneity, AIT lasts as a defiant entity, leading to a thorny treatment course, particularly in pediatrics. AIT can be classified as either type 1, type 2 or mixed form based on its pathophysiology. Differentiating between the main AIT subtypes is quite relevant, since there is specific treatment for both, however, this distinction may be difficult in clinical practice. We describe a rare case of AIT in a pediatric patient, with an uncommon congenital cardiac malformation, that started amiodarone therapy due to paroxysmal supraventricular tachycardia. AIT was reported 26 months after drug onset, with a sudden and explosive emerging. This case highlights the current AIT management challenges on the highdemanding pediatric field pursuing, ultimately, an enhanced patient´s care. PAGEPress Scientific Publications, Pavia, Italy 2019-09-24 /pmc/articles/PMC6769358/ /pubmed/31579213 http://dx.doi.org/10.4081/pr.2019.8166 Text en ©Copyright: the Author(s), 2019 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Oliveira, Sofia Marques, Bernardo Laranjo, Sérgio Lopes, Lurdes Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title | Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title_full | Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title_fullStr | Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title_full_unstemmed | Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title_short | Amiodarone-induced thyrotoxicosis in a pediatric patient: A rare and demanding clinical case |
title_sort | amiodarone-induced thyrotoxicosis in a pediatric patient: a rare and demanding clinical case |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769358/ https://www.ncbi.nlm.nih.gov/pubmed/31579213 http://dx.doi.org/10.4081/pr.2019.8166 |
work_keys_str_mv | AT oliveirasofia amiodaroneinducedthyrotoxicosisinapediatricpatientarareanddemandingclinicalcase AT marquesbernardo amiodaroneinducedthyrotoxicosisinapediatricpatientarareanddemandingclinicalcase AT laranjosergio amiodaroneinducedthyrotoxicosisinapediatricpatientarareanddemandingclinicalcase AT lopeslurdes amiodaroneinducedthyrotoxicosisinapediatricpatientarareanddemandingclinicalcase |