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Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)

The involvement of chromosome changes in the initial steps of speciation is controversial. Here we examine diversification trends within the mole voles Ellobius, a group of subterranean rodents. The first description of their chromosome variability was published almost 40 years ago. Studying the G-b...

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Autores principales: Romanenko, Svetlana A., Lyapunova, Elena A., Saidov, Abdusattor S., O’Brien, Patricia C.M., Serdyukova, Natalia A., Ferguson-Smith, Malcolm A., Graphodatsky, Alexander S., Bakloushinskaya, Irina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769443/
https://www.ncbi.nlm.nih.gov/pubmed/31510061
http://dx.doi.org/10.3390/ijms20184466
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author Romanenko, Svetlana A.
Lyapunova, Elena A.
Saidov, Abdusattor S.
O’Brien, Patricia C.M.
Serdyukova, Natalia A.
Ferguson-Smith, Malcolm A.
Graphodatsky, Alexander S.
Bakloushinskaya, Irina
author_facet Romanenko, Svetlana A.
Lyapunova, Elena A.
Saidov, Abdusattor S.
O’Brien, Patricia C.M.
Serdyukova, Natalia A.
Ferguson-Smith, Malcolm A.
Graphodatsky, Alexander S.
Bakloushinskaya, Irina
author_sort Romanenko, Svetlana A.
collection PubMed
description The involvement of chromosome changes in the initial steps of speciation is controversial. Here we examine diversification trends within the mole voles Ellobius, a group of subterranean rodents. The first description of their chromosome variability was published almost 40 years ago. Studying the G-band structure of chromosomes in numerous individuals revealed subsequent homologous, step-by-step, Robertsonian translocations, which changed diploid numbers from 54 to 30. Here we used a molecular cytogenetic strategy which demonstrates that chromosomal translocations are not always homologous; consequently, karyotypes with the same diploid number can carry different combinations of metacentrics. We further showed that at least three chromosomal forms with 2n = 34 and distinct metacentrics inhabit the Pamir-Alay mountains. Each of these forms independently hybridized with E. tancrei, 2n = 54, forming separate hybrid zones. The chromosomal variations correlate slightly with geographic barriers. Additionally, we confirmed that the emergence of partial or monobrachial homology appeared to be a strong barrier for hybridization in nature, in contradistinction to experiments which we reported earlier. We discuss the possibility of whole arm reciprocal translocations for mole voles. Our findings suggest that chromosomal translocations lead to diversification and speciation.
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spelling pubmed-67694432019-10-30 Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia) Romanenko, Svetlana A. Lyapunova, Elena A. Saidov, Abdusattor S. O’Brien, Patricia C.M. Serdyukova, Natalia A. Ferguson-Smith, Malcolm A. Graphodatsky, Alexander S. Bakloushinskaya, Irina Int J Mol Sci Article The involvement of chromosome changes in the initial steps of speciation is controversial. Here we examine diversification trends within the mole voles Ellobius, a group of subterranean rodents. The first description of their chromosome variability was published almost 40 years ago. Studying the G-band structure of chromosomes in numerous individuals revealed subsequent homologous, step-by-step, Robertsonian translocations, which changed diploid numbers from 54 to 30. Here we used a molecular cytogenetic strategy which demonstrates that chromosomal translocations are not always homologous; consequently, karyotypes with the same diploid number can carry different combinations of metacentrics. We further showed that at least three chromosomal forms with 2n = 34 and distinct metacentrics inhabit the Pamir-Alay mountains. Each of these forms independently hybridized with E. tancrei, 2n = 54, forming separate hybrid zones. The chromosomal variations correlate slightly with geographic barriers. Additionally, we confirmed that the emergence of partial or monobrachial homology appeared to be a strong barrier for hybridization in nature, in contradistinction to experiments which we reported earlier. We discuss the possibility of whole arm reciprocal translocations for mole voles. Our findings suggest that chromosomal translocations lead to diversification and speciation. MDPI 2019-09-10 /pmc/articles/PMC6769443/ /pubmed/31510061 http://dx.doi.org/10.3390/ijms20184466 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Romanenko, Svetlana A.
Lyapunova, Elena A.
Saidov, Abdusattor S.
O’Brien, Patricia C.M.
Serdyukova, Natalia A.
Ferguson-Smith, Malcolm A.
Graphodatsky, Alexander S.
Bakloushinskaya, Irina
Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title_full Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title_fullStr Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title_full_unstemmed Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title_short Chromosome Translocations as a Driver of Diversification in Mole Voles Ellobius (Rodentia, Mammalia)
title_sort chromosome translocations as a driver of diversification in mole voles ellobius (rodentia, mammalia)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769443/
https://www.ncbi.nlm.nih.gov/pubmed/31510061
http://dx.doi.org/10.3390/ijms20184466
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