Cargando…
Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial
Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times d...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769465/ https://www.ncbi.nlm.nih.gov/pubmed/31489910 http://dx.doi.org/10.3390/nu11092126 |
_version_ | 1783455243473780736 |
---|---|
author | Hibi, Masanobu Hari, Sayaka Yamaguchi, Tohru Mitsui, Yuki Kondo, Sumio Katashima, Mitsuhiro |
author_facet | Hibi, Masanobu Hari, Sayaka Yamaguchi, Tohru Mitsui, Yuki Kondo, Sumio Katashima, Mitsuhiro |
author_sort | Hibi, Masanobu |
collection | PubMed |
description | Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 times daily (9M). Blood glucose was monitored on Day 3 using a continuous glucose monitoring system, and subjects underwent a 75-g oral glucose tolerance test (OGTT) on Day 4. Daytime maximum blood glucose, glucose range, duration of glucose ≥180 mg/dL, and nighttime maximum glucose were significantly lower in the NGT/9M condition than in the NGT/3M condition. Similar findings were observed in the IFG subjects, with a lower daytime and nighttime maximum glucose and glucose range, and a significantly higher daytime minimum glucose in the 9M condition than in the 3M condition. The OGTT results did not differ significantly between NGT/3M and NGT/9M conditions. In contrast, the incremental area under the curve tended to be lower and the maximum plasma glucose concentration was significantly lower in the IFG/9M condition than in the IFG/3M condition. In IFG subjects, the 9M condition significantly improved glucose metabolism compared with the 3M condition. Higher meal frequency may increase glucagon-like peptide 1 secretion and improve insulin secretion. |
format | Online Article Text |
id | pubmed-6769465 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-67694652019-10-30 Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial Hibi, Masanobu Hari, Sayaka Yamaguchi, Tohru Mitsui, Yuki Kondo, Sumio Katashima, Mitsuhiro Nutrients Article Effects of meal frequency on blood glucose levels and glucose metabolism were evaluated over 3 days in adult males with normal glucose tolerance (NGT, n = 9) or impaired fasting glucose (IFG, n = 9) in a randomized, crossover comparison study. Subjects were provided with an isocaloric diet 3 times daily (3M) or 9 times daily (9M). Blood glucose was monitored on Day 3 using a continuous glucose monitoring system, and subjects underwent a 75-g oral glucose tolerance test (OGTT) on Day 4. Daytime maximum blood glucose, glucose range, duration of glucose ≥180 mg/dL, and nighttime maximum glucose were significantly lower in the NGT/9M condition than in the NGT/3M condition. Similar findings were observed in the IFG subjects, with a lower daytime and nighttime maximum glucose and glucose range, and a significantly higher daytime minimum glucose in the 9M condition than in the 3M condition. The OGTT results did not differ significantly between NGT/3M and NGT/9M conditions. In contrast, the incremental area under the curve tended to be lower and the maximum plasma glucose concentration was significantly lower in the IFG/9M condition than in the IFG/3M condition. In IFG subjects, the 9M condition significantly improved glucose metabolism compared with the 3M condition. Higher meal frequency may increase glucagon-like peptide 1 secretion and improve insulin secretion. MDPI 2019-09-06 /pmc/articles/PMC6769465/ /pubmed/31489910 http://dx.doi.org/10.3390/nu11092126 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hibi, Masanobu Hari, Sayaka Yamaguchi, Tohru Mitsui, Yuki Kondo, Sumio Katashima, Mitsuhiro Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title_full | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title_fullStr | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title_full_unstemmed | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title_short | Effect of Short-Term Increase in Meal Frequency on Glucose Metabolism in Individuals with Normal Glucose Tolerance or Impaired Fasting Glucose: A Randomized Crossover Clinical Trial |
title_sort | effect of short-term increase in meal frequency on glucose metabolism in individuals with normal glucose tolerance or impaired fasting glucose: a randomized crossover clinical trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769465/ https://www.ncbi.nlm.nih.gov/pubmed/31489910 http://dx.doi.org/10.3390/nu11092126 |
work_keys_str_mv | AT hibimasanobu effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial AT harisayaka effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial AT yamaguchitohru effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial AT mitsuiyuki effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial AT kondosumio effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial AT katashimamitsuhiro effectofshorttermincreaseinmealfrequencyonglucosemetabolisminindividualswithnormalglucosetoleranceorimpairedfastingglucosearandomizedcrossoverclinicaltrial |