Cargando…

Multigene Panel Testing Increases the Number of Loci Associated with Gastric Cancer Predisposition

The main gene involved in gastric cancer (GC) predisposition is CDH1, the pathogenic variants of which are associated with diffuse-type gastric cancer (DGC) and lobular breast cancer (LBC). CDH1 only explains a fraction (10–50%) of patients suspected of DGC/LBC genetic predisposition. To identify no...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tedaldi, Gianluca, Pirini, Francesca, Tebaldi, Michela, Zampiga, Valentina, Cangini, Ilaria, Danesi, Rita, Arcangeli, Valentina, Ravegnani, Mila, Abou Khouzam, Raefa, Molinari, Chiara, Oliveira, Carla, Morgagni, Paolo, Saragoni, Luca, Bencivenga, Maria, Ulivi, Paola, Amadori, Dino, Martinelli, Giovanni, Falcini, Fabio, Ranzani, Guglielmina Nadia, Calistri, Daniele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6769562/ https://www.ncbi.nlm.nih.gov/pubmed/31514334 http://dx.doi.org/10.3390/cancers11091340

Ejemplares similares

Male Breast Cancer: Results of the Application of Multigene Panel Testing to an Italian Cohort of Patients
por: Tedaldi, Gianluca, et al.
Publicado: (2020)

Multiple-gene panel analysis in a case series of 255 women with hereditary breast and ovarian cancer
por: Tedaldi, Gianluca, et al.
Publicado: (2017)

E-cadherin Downregulation and microRNAs in Sporadic Intestinal-Type Gastric Cancer
por: Rossi, Tania, et al.
Publicado: (2019)

Prevalence of a BRCA2 Pathogenic Variant in Hereditary-Breast-and-Ovarian-Cancer-Syndrome Families with Increased Risk of Pancreatic Cancer in a Restricted Italian Area
por: Zampiga, Valentina, et al.
Publicado: (2023)

Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer
por: Khouzam, Raefa Abou, et al.
Publicado: (2016)

Case Report: A BRCA2 Mutation Identified Through Next-Generation Sequencing in a Birt–Hogg–Dubè Syndrome Family
por: Bandini, Erika, et al.
Publicado: (2022)

A Novel FLCN Variant in a Suspected Birt–Hogg–Dubè Syndrome Patient
por: Bandini, Erika, et al.
Publicado: (2023)

First evidence of a large CHEK2 duplication involved in cancer predisposition in an Italian family with hereditary breast cancer
por: Tedaldi, Gianluca, et al.
Publicado: (2014)

Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer
por: Tedaldi, Gianluca, et al.
Publicado: (2021)

Comprehensive analysis of DNA damage repair genes reveals pathogenic variants beyond BRCA and suggests the need for extensive genetic testing in pancreatic cancer
por: Rapposelli, Ilario Giovanni, et al.
Publicado: (2021)

Clinical Impact of Next-Generation Sequencing Multi-Gene Panel Highlighting the Landscape of Germline Alterations in Ovarian Cancer Patients
por: Gurioli, Giorgia, et al.
Publicado: (2022)

DNA Methylation profiles as predictors of recurrence in non muscle invasive bladder cancer: an MS-MLPA approach
por: Casadio, Valentina, et al.
Publicado: (2013)

MUTYH-associated polyposis (MAP), the syndrome implicating base excision repair in inherited predisposition to colorectal tumors
por: Venesio, Tiziana, et al.
Publicado: (2012)

EGFR methylation and outcome of patients with advanced colorectal cancer treated with cetuximab
por: CHIADINI, ELISA, et al.
Publicado: (2015)

Instability of Non-Standard Microsatellites in Relation to Prognosis in Metastatic Colorectal Cancer Patients
por: Pirini, Francesca, et al.
Publicado: (2020)

Impact of the time interval between primary or interval surgery and adjuvant chemotherapy in ovarian cancer patients
por: Farolfi, Alberto, et al.
Publicado: (2023)

Inherited breast cancer predisposition in Asians: multigene panel testing outcomes from Singapore
por: Wong, Edward S Y, et al.
Publicado: (2016)

Novel genetic mutations detected by multigene panel are associated with hereditary colorectal cancer predisposition
por: Martin-Morales, Lorena, et al.
Publicado: (2018)

Gallbladder Cancer Predisposition: A Multigenic Approach to DNA-Repair, Apoptotic and Inflammatory Pathway Genes
por: Srivastava, Kshitij, et al.
Publicado: (2011)

CDKN1A upregulation and cisplatin-pemetrexed resistance in non-small cell lung cancer cells
por: Zamagni, Alice, et al.
Publicado: (2020)

Utilization of multigene panels in hereditary cancer predisposition testing: analysis of more than 2,000 patients
por: LaDuca, Holly, et al.
Publicado: (2014)

Contribution of New Adenomatous Polyposis Predisposition Genes in an Unexplained Attenuated Spanish Cohort by Multigene Panel Testing
por: Lorca, Víctor, et al.
Publicado: (2019)

Discrepancies between VEGF −1154 G>A Polymorphism Analysis Performed in Peripheral Blood Samples and FFPE Tissue
por: Marisi, Giorgia, et al.
Publicado: (2014)

Detection of KRAS mutant alleles in circulating cell-free tumor DNA in colorectal cancer patients resistant to cetuximab
por: Del Re, Marzia, et al.
Publicado: (2014)

Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype
por: Calin, George, et al.
Publicado: (2001)

Genetic Predisposition to Colorectal Cancer: How Many and Which Genes to Test?
por: Rebuzzi, Francesca, et al.
Publicado: (2023)

Genomic alterations in rectal tumors and response to neoadjuvant chemoradiotherapy: an exploratory study
por: Molinari, Chiara, et al.
Publicado: (2011)

Recurrence in node-negative advanced gastric cancer: Novel findings from an in-depth pathological analysis of prognostic factors from a multicentric series
por: Baiocchi, Gian Luca, et al.
Publicado: (2017)

Predictive role of multiple gene alterations in response to cetuximab in metastatic colorectal cancer: A single center study
por: Ulivi, Paola, et al.
Publicado: (2012)

The current role of telomerase in the diagnosis of bladder cancer
por: Bravaccini, Sara, et al.
Publicado: (2009)

Promoter methylation of tumor suppressor genes in pre-neoplastic lesions; potential marker of disease recurrence
por: Rengucci, Claudia, et al.
Publicado: (2014)

BRCA1 p.His1673del is a pathogenic mutation associated with a predominant ovarian cancer phenotype
por: Zuntini, Roberta, et al.
Publicado: (2017)

Atypical polypoid adenomyoma of the endometrium: diagnosis and treatment. A case report
por: Domeniconi, Lucia, et al.
Publicado: (2020)

Tumor hypoxia: an important regulator of tumor progression or a potential modulator of tumor immunogenicity?
por: Hassan Venkatesh, Goutham, et al.
Publicado: (2021)

Circulating Plasma Levels of miR-20b, miR-29b and miR-155 as Predictors of Bevacizumab Efficacy in Patients with Metastatic Colorectal Cancer
por: Ulivi, Paola, et al.
Publicado: (2018)

Tumor Hypoxia Regulates Immune Escape/Invasion: Influence on Angiogenesis and Potential Impact of Hypoxic Biomarkers on Cancer Therapies
por: Abou Khouzam, Raefa, et al.
Publicado: (2021)

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition
por: Engelsen, Agnete S. T., et al.
Publicado: (2022)

The Effect of Hypoxia and Hypoxia-Associated Pathways in the Regulation of Antitumor Response: Friends or Foes?
por: Abou Khouzam, Raefa, et al.
Publicado: (2022)

Evolution and variation of multigene families
por: Ohta, Tomoko
Publicado: (1980)

Hypoxia, a Targetable Culprit to Counter Pancreatic Cancer Resistance to Therapy
por: Abou Khouzam, Raefa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_97l4evd83lqlia6nq89kglbclg